A type of nuclear proteins that participate in the potentiation of transcription of genes that are responsive to ligand-dependent transcription factors. They belong to several families, including the p160 coactivators and the CBP/p300 molecules.
[co- + activator]
References in periodicals archive ?
2],[3] The Hippo signaling pathway consists primarily of LATS1/2, MST1/2, WW45, and the transcriptional effector Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ).
Skeletal muscle transcriptional coactivator PGC-1 alpha mediates mitochondrial, but not metabolic, changes during calorie restriction.
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha.
The aim of this study was to determine the association of Gly482Ser variant of proliferator activator receptor I3 coactivator 1[alpha] (PPARGC1[alpha]) gene with diabetes in Pakistani population.
Reverse memory loss associated with Alzheimer's disease (AD): Working with mice modified to develop a form of AD, researchers focused on the protein CRTC1 (CREB-regulated transcription coactivator 1), which is essential to the process of forming associative memories (the ability to recall places, events and people), which are disrupted in people with AD.
The steroid receptor coactivator (SRC) family in mice contains three homologous members, SRC-1/NCoA-1, SRC-2/NCoA-2, and SRC-3/NCoA-3.
Nicotinamide riboside restores cognition through an upregulation of proliferatoractivated receptor-gamma coactivator 1alpha regulated beta-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models.
Tumor protein p53, nuclear factor [kappa]B (NF[kappa]B), FOXO (Forkhead box O) proteins, estrogen receptor [alpha], liver X receptor, SRY-box 9 (SOX9), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1[alpha]), and p300 coactivator are all part of the critical downstream targets of SIRT1 [25-28].
Our previous ERC Advanced Grant TRANSIT enabled us to provide molecular insights into yeast Pol II initiation and its regulation by the Mediator coactivator complex (Plaschka et al.
We asked whether immunohistochemistry directed toward NF2 (merlin), LATS2, and their downstream effector YAP/TAZ (a complex of Yes-associated protein and transcriptional coactivator with PDZbinding motif) (6) could serve as adjunctive tests when a question of mesothelioma versus a benign reaction arises.