Immunology The delivery of a 2nd signal from an antigen-presenting cell to a T cell, which rescues an activated T cell from anergy, allowing it to produce the lymphokines necessary for production of additional T cells
Many major disease targets are trimerization-dependent such as the tumor necrosis factor superfamily (involved in extrinsic apoptosis, immune co-stimulation and inflammation) as well as enveloped RNA virus antigens responsible for entry into host cells.
Lius contributions to the field include pioneering work in the concept of T cell co-stimulation and cancer immunity, the relationship between innate and adaptive immunity and non-self-discrimination by the innate immune system.
Helping to advance clinical understanding of autoimmune conditions is a key focus of our immunoscience research, and were proud to introduce ORENCIA, a selective T-cell co-stimulation modulator, as an additional treatment option for PsA.
Furthermore, in vitro we investigated mRNA expression for IL-22 and IL-22 BP, and IL 22 receptor after co-stimulation of peripheral blood mononuclear cells (PBMC) from individuals with asthma and normal controls with Th2 cytokines IL-4, IL-9, and GM-CSF in a time-dependent manner.
Annotine increased mDC expression of surface molecules linked with antigen presentation and co-stimulation and increased secretion of pro-inflammatory cytokines following co-culture with allogeneic [CD4.sup.+] T cells