Its biosimilarity has been studied in healthy volunteers who have no comorbidities, require no co-medication
and are immunocompetent.
Aim: To investigate the effects of CLNAZ co-medication
, patient gender, age and CLZ dosage on serum concentration of CLZ and norclozapine (N-CLZ) in individuals with schizophrenia.
-- Patients must be willing to receive oral folic acid (at least 5 mg/week or as per local practice) or equivalent during the entire study (mandatory co-medication
for MTX treatment).
Duration n (%) <1 month 2 (0.5%) 1 to <6 month 16 (3.7%) 0.5-1 year 34 (7.8%) 1 to <2 years 45 (10.3%) 2 to <5 years 78 (17.9%) [greater than or equal to] 5 years 253 (58.0%) Co-medication
patterns and reasons for discontinuation
For patients between ages 20 and 60, the effect of co-medication
was considered weak.
Based on these findings, Malik recommended that patients with a longer history of alcohol abuse or dependence undergo dual-energy X-ray absorptiometry, a measurement of BMD, especially when other risk factors such as co-medication
or smoking are present.
Co-morbidities and co-medication
. The most prevalent co-morbidities were hypertension, dislipidemia, and hypothyroidism and the most frequent long term complications can be seen in Table 2.
* Treatment and medication should be tailored to an individual's seizure type, co-medication
, lifestyle, and preferences.
The cover picture of Volume 18 addresses the possibility of a co-medication
of bioactive natural products with chemotherapeutics or antibiotics.
The shortcomings of most of these reports include difficulties regarding the assessment of co-medication
with drugs and dietary supplements (DDS) and inaccuracies regarding the treatment duration, dose, natural course of the liver function tests and exclusion of unrelated diseases.
Further comments have been submitted on Valerian root within the 3-month consultation period, relating to the HMPC' recommendation to avoid co-medication
with other sedatives.
Based on current clinical and experimental data, co-medication
with SWE should be avoided in patients who are taking anticoagulants of the coumarin type (e.g.