But in order to soundly assess these poorly controlled observations, stratification of treatment allocation of pharmacotherapy should be considered in future trials, according to the presence of concomitant enteral nutrition, to better understand the clinical implications of this
co-intervention, or head-to-head randomisation should compare enteral nutrition alone to acid suppressive pharmacoprophylaxis.
These estimates were unchanged after imputing missing data, and estimates of effect in trials with higher loss to follow-up or a possibility of
co-intervention compared with those with lower loss to follow-up and no
co-intervention did not differ significantly (p=0.
There was no known
co-intervention, and the time-period of 2 weeks between the assessments was too short for the acquisition of further experience to explain the improvement.
That factorial trial demonstrated improvement in quadriceps muscle cross-sectional area in response to exercise training--an effect that was still evident even when the anabolic steroid nandrolone decanoate was used as a
co-intervention.
One study was not included because it used contact lenses as a
co-intervention.
method described and appropriate Contamination/ No mention of ways to control score 0;
co-intervention (/4) for contamination or
co-intervention some patients received some score 2; sort of contamination or
co-intervention assumed that no contamination or
co-intervention took place due to immediate follow-up score 3; contamination and score 4.
This study involved very few subjects (n = 17), no significant follow-up period, provided no information with respect to contamination or
co-intervention and provided minimal information on blinding strategies.
Due to the lack of long-term follow-up care and the use of a single treatment intervention, contamination and
co-intervention grading had to be assumed in 4 of the 8 studies which may have further influenced the overall quality of these studies.
The Company's initial results point to the importance of drug delivery systems and the impact of
co-interventions.
there are no unexpected
co-interventions, such as medications, supplementary therapies, and behaviors during trials.
Using the risk of bias scoring criteria, (23,24) included articles were individually scored based on the following criteria: assignment of patients, similarity of baseline characteristics, use of prognostic stratification, relevance of clinical outcomes/significance, blinding strategies, statistical significance,
co-interventions, compliance of subjects to the study procedures and follow-up levels.
Several risks of bias need to be considered, including but not limited to blinding of participants and personnel, completeness of outcome data, financial interests, compliance and
co-interventions.
