clusterin


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clusterin

 [klus´ter-in]
a multifunctional glycoprotein with roles in the metabolism and transport of lipids and membrane fragments, secretion of hormones, reproductive biology, inhibition of assembly of the membrane attack complex of complement activation, programmed cell death, and modulation of intercell interactions; its expression is enhanced in tissue injury and remodeling as well as in degenerative diseases such as alzheimer's disease.

clusterin

(klŭs'tĕr-in),
Heterodimeric highly conserved secreted glycoprotein, which is expressed in a wide variety of tissues and found in all human fluids; implicated in physiologic processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis.
Synonym(s): apolipoprotein J

clusterin

(klus'te-rin) [ cluster + -in],

CLU.

A multifunctional cell-protective glycoprotein (molecular weight 75-80 kDa) found in many tissues. High levels of CLU are found in cells undergoing apoptosis. Synonym: apolipoprotein J
References in periodicals archive ?
The role of human kallikrein 6, clusterin and adiponectin as potential blood biomarkers of dementia.
Another AD risk gene is clusterin (CLU) known as apolipoprotein J (APOJ) (14), and it directly binds A[beta] and regulates the A[beta] pathology (15).
The tumor cells consistently express vimentin, with variable positivity for D2-40, CD34, CD68, smooth muscle actin, keratin, and p53, but lack other mesenchymal, epithelial markers, such as S100 protein, desmin, neuron-specific enolase, epithelial membrane antigen, HMB-45, clusterin, and leukocyte markers (CD15, CD30, CD45).
In AD, amyloid precursor protein (APP) and presenilin (PS) are already the definitive virulence genes.[1] For SAD >90% of AD, major influencing genes include apolipoprotein E (ApoE) gene, clusterin gene, complement receptor 1 gene, and phospholipids bind to clathrin protein (PICALM) gene.[2] Along with the development of genetic research into AD, more new genetic loci for AD have been discovered, including cholesterol metabolism gene (CH25H, ABCAL, and CH24H),[3] Sterol O-acyltransferase (Soat1) and prostaglandin-endoperoxide synthase 2 (Ptgs2)[4] genes, and angiotensin-converting enzyme gene [5] are some of these.
Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney.
Salminen, "Valproic acid stimulates clusterin expression in human astrocytes: implications for Alzheimer's disease," Neuroscience Letters, vol.
Mattsson et al., "Complement and clusterin in the spinal cord dorsal horn and gracile nucleus following sciatic nerve injury in the adult rat," Neuroscience, vol.
Abozeed, "Diagnostic evaluation of urinary angiogenin (ANG) and clusterin (CLU) as biomarker for bladder cancer," Pathology & Oncology Research, vol.
The tumor cells were also negative for HMB-45, CD15, CD20, CD21, CD23, CD43, CD45, desmin, myogenin, calretinin, myeloperoxidase, D2-40, CD68, and clusterin (Figure 1(e)).
have demonstrated that exosomes are involved in cell-to-cell contact during immune responses for tumorigenesis, infectious diseases, allergies, and autoimmune diseases [42], for example, during myocardial infractions in the presence of clusterin in exosomes obtained from pericardial fluids of patients [124].