The principal features of PDP include clubbing of the digits, periosteal new bone formation, furrows and coarse facial features, and cutis verticis gyrata.
The PDGF brings fibroblast proliferation with increased vascularity and permeability, and consequently results in clubbing of the digits and VEGF has a function in angiogenesis and osteoblastic differentiation.
Keywords: Primary Hypertrophic Osteoarthropathy(PHOA), Clubbing of the digits
5 This syndrome includes clubbing of the digits
periosteal new bone formation coarsening of facial features oiliness and furrowing of the skin of face as well as that of scalp seborrheic hyperplasia and hyperhidrosis of hands and feet.
Pachydermoperiostosis (PDP), also referred to as primary hypertrophic osteoarthropathy (HOA), is a rare hereditary disorder characterized by clubbing of the digits
, thickening of the skin, and periosteal changes in the long bones.
Mild temporal wasting, absence of oral thrush, poor dentition, positive jugular venous distention, bilateral crackles in the lungs, a decrescendo diastolic murmur in the left sternal border, "water hammer" pulses, and clubbing of the digits