A: Hemophilia is a bleeding disorder in which blood has insufficient amount of certain proteins called blood clotting factors
that are needed for blood clotting or coagulation, i.e., the formation of a blood clot or coagulate.
Additionally, the presence of specific inhibitors, commonly targeting factor VIII, can cause clotting factor
Hemostasis is a complex interaction between platelets and clotting factors
, all of which must be sufficiently present to stop bleeding.
The missing clotting factor
is injected into the bloodstream using a needle.
Infusing a crystalloid solution (normal saline or lactated Ringer's solution) or stored packed red blood cells without clotting factors
into a hemorrhaging patient will dilute the clotting factors
and can actually make the patient more coagulopathic.
The most common form of the disease is hemophilia A, or classic hemophilia, in which the clotting factor
VIII is either deficient or defective.
This clotting factor
concentrate is the first biologic product approved for patients with von Willebrand disease (vWD) who are undergoing surgery or invasive procedures and for whom desmopressin is either ineffective or contraindicated, according to the FDA.
In its bite, the tiger keelback delivers slow-acting salivary toxins, which disable a clotting factor
in the blood of its victims.
Coverage includes include understanding blood and the circulatory system; anemia and other hemoglobin diseases such as sickle cell anemia; cancer of the blood, including the various types of leukemia and associated bone marrow disorders; bleeding disorders such as hemophilia and clotting factor
deficiencies; disorders of the veins and blood vessels (such as varicose veins); disorders of the arteries (such as high blood pressure) and clotting; and inflammatory and infectious circulatory disorders such as vasculitis, thrombosis, and stroke.
By all accounts, this represents a dramatic reduction in the amount of reimbursement that provides for blood clotting factor
and a few ancillary supplies.
The proteolytic enzyme is preferably selected from the group consisting of thrombin, activated clotting factor
, activated fibrinolytic factor, and activated component of the complement system.
Hayden Lewis,from the campaign group Haemophilia Wales, was infected with HIV by a blood clotting factor
he was given in 1985 and was told about his Hepatitis C in 1993.