clostridial myonecrosis


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

gas gan·grene

gangrene occurring in a wound infected with various anaerobic spore-forming bacteria, especially Clostridium perfringens and C. novyi, which cause rapidly advancing crepitation of the surrounding tissues, due to gas liberated by bacterial fermentation, and constitutional toxic and septic symptoms including cytotoxic damage to kidney, liver, and other organs.

clostridial myonecrosis

Gas gangrene, necrotizing subcutaneous infection Emergency medicine A rapidly progressive, life-threatening form of gangrene that is a rare complication of 'dirty' traumatic wounds, which are infected with Clostridium spp Etiology War wounds, bee stings, venipuncture; CM is due to production of toxins, especially alpha toxin, leading to tissue necrosis, shock Management Surgical decompression, excision of necrotic tissue, penicillin, hyperbaric oxygen. See Hyperbaric oxygen therapy, Necrotizing fasciitis.
References in periodicals archive ?
Novel real-time PCR assay for simultaneous detection and differentiation of Clostridium chauvoei and Clostridium septicum in clostridial myonecrosis. Journal of Clinical Microbiology, v.48, p.1093-1098, 2010.
Clostridial myonecrosis is most commonly seen in wartime injuries or among victims of natural disasters due to delayed treatment of injuries.
Excruciating pain is a significant clinical symptom of clostridial myonecrosis. Diagnosis: The most important discriminative information to be established in patients with soft-tissue infection is the presence of a necrotizing component.
Clostridial myonecrosis comprise necrotizing soft tissue infections caused by one or more pathogenic clostridia, including Clostridium septicum, Clostridium chauvoei, Clostridium novyi type A, Clostridium perfringens type A, and Clostridium sordellii.
Laboratory diagnosis of clostridial myonecrosis is commonly based on a fluorescent antibody test (FAT) or isolation of the etiological agent.
The diagnosis of clostridial myonecrosis is based on the clinical history, anatomical and pathological findings and identification of the etiological agent involved, which can be accomplished through bacterial isolation, direct immunofluorescence or IHC.