Novel real-time PCR assay for simultaneous detection and differentiation of Clostridium chauvoei and Clostridium septicum in clostridial myonecrosis
. Journal of Clinical Microbiology, v.48, p.1093-1098, 2010.
is most commonly seen in wartime injuries or among victims of natural disasters due to delayed treatment of injuries.
Excruciating pain is a significant clinical symptom of clostridial myonecrosis
. Diagnosis: The most important discriminative information to be established in patients with soft-tissue infection is the presence of a necrotizing component.
Clostridial myonecrosis comprise necrotizing soft tissue infections caused by one or more pathogenic clostridia, including Clostridium septicum, Clostridium chauvoei, Clostridium novyi type A, Clostridium perfringens type A, and Clostridium sordellii.
Laboratory diagnosis of clostridial myonecrosis is commonly based on a fluorescent antibody test (FAT) or isolation of the etiological agent.
The diagnosis of clostridial myonecrosis
is based on the clinical history, anatomical and pathological findings and identification of the etiological agent involved, which can be accomplished through bacterial isolation, direct immunofluorescence or IHC.