8 Benzodiazepines Oxazepam 100 3 Alprazolam 85 167 [alpha]-Hydroxyalprazolam 75 122 Bromazepam 50 1 Clorazepate
21 39 Diazepam 155 >500 Flurazepam 13 17 Lorazepam 15 0 Medazepam 25 1.
In January 1998, Mylan raised the price of clorazepate
by 3,218 percent: Clorazepate
is a generic version of Abbott Laboratories' Tranxene that is prescribed nearly three million times each year in the United States.
Clonazepam is useful for the chronic treatment of absence and myoclonic seizures and clorazepate
is effective in partial seizures when used with other AEDs.
Among the more commonly used long half-life benzodiazepine drugs are: clonazepam (Klonopin), diazepam (T-Quil, Valium, Valrelease, Vazepam, Zetran), clorazepate
(Gen-XENE, Tranxene-SD, Tranxene T-Tab), chlordiazepoxide (Librium, Libritabs, Lipoxide), and flurazepam (Dalmane).
45) Ergotarnine (various) Cold and allergy antihistamines: astemizole (Hismanal), loratadine (Claritin) terfenadine (Seldane) Gastrointestinal: cisapride (Propulsid) very limited clinical experience Psychotropic (antidepressant): fluoxetine (Prozac) bupropion (Wellbutrin) desipramine (Norpramin) Psychotropic (neuroleptic): clozapine (Clozaril) very limited clinical experience pimozide (Orap) Sedative/hypnotic: alprazolam (Xanax) clorazepate
(Tranxene) diazepam (Valium) Temazepam (Restoril) estazolam (ProSom) Lorazepam (Ativan) flurazeparn (Dalmane) midazolam (Versed) triazolam (Halcion) zolpidem (Ambien)
0 million from Mylan's co-defendants in the lorazepam and clorazepate
Clonazepam, chlordiazepoxide, clorazepate
, and oxazepam may be less reinforcing for SUD patients than diazepam, lorazepam, alprazolam, estazolam, or triazolam.
In contrast, first-generation AEDs that do not appear to be associated with a significant risk of birth defects include the benzodiazepines (clonazepam [Klonopin], clorazepate
[Tranxene], diazepam [Valium], and lorazepam [Ativan]) and succinimides (ethosuximide [Zarontin] and methsuximide [Celontin]).
2000) (considering: (1) "whether the district court's ruling is likely dispositive of litigation by creating 'death knell' for either plaintiff or defendant"; (2) "whether the petitioner has shown substantial weakness in class certification decision, such that decision likely constitutes abuse of discretion"; (3) "whether the appeal will permit resolution of unsettled legal issue that is important to particular litigation as well as important in itself'; (4) "nature and status of litigation before the district court"; and (5) "likelihood that future events may make immediate appellate review more or less appropriate"); In re Lorazepam & Clorazepate
TABLE 4 Oral Benzodiazepine Comparison  Half-life [*] Drug Hours Days Faster Onset Triazolam (Halcion) 1-5 - Clorazepate
(Tranxene) - 1-3 Diazepam (Valium, Valrelease, - 1-3 Zetram) Quazepam (Doral) - 2-3 Flurazepam (Dalmane) - 2-5 (with active metabolites) Slower Onset Oxazepam (Serax) 3-12 - Temazepam (Restoril) 3-20 - Alprazolam (Xanax) 6-20 - Lorazepam (Ativan) 10-20 - Estazolam (ProSom) - 1/2-1 Clonazepam (Klonopin) - 3/4-2 Chlordiazepoxide (Librium, - 1-3 Mitran) Halazepam (Paxipam) - 3+ Prazepam (Centrax) - 3+ (*)The time involved for one half of an administered drug to be lost via metabolism and/or excretion.
FOOD AND DRUG ADMINISTRATION APPROVED BENZODIAZEPINES Indication Drug Insomnia Flurazepam Temazepam Triazolam Epilepsy Clonazepam Clorazepate
Diazepam Alcohol withdrawal Clonazepam Clorazepate
Diazepam Alcohol withdrawal Chlordiazepoxide Chlorazepate Diazepam Oxazepam Anxiety associated with Alprazolam depression Oxazepam Muscle spasm Diazepam Anxiety Alprazolam Chlordiazepoxide Chlorazepate Diazepam Halazepam Lorazepam Oxazepam Prazepam Preoperative medication Midazolam Chlordiazepoxide
In March 2003, Mylan reached a tentative settlement of a class action lawsuit concerning Mylan's 1998 lorazepam and clorazepate
anti-trust litigation and received an arbitration decision in a dispute involving verapamil.