clopidogrel


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Related to clopidogrel: clopidogrel bisulfate

clopidogrel

 [klo-pid´ah-grel]
an inhibitor of platelet aggregation, used in the form of the bisulfate salt to prevent formation of thrombi and prevent myocardial infarction, stroke, and vascular death in patients with atherosclerosis; administered orally.

clopidogrel

(klō-pĭd′ə-grĕl′)
n.
A drug, C16H16ClNO2S, given in the form of its bisulfate, that inhibits platelet aggregation and is used in the treatment of patients with peripheral arterial disease, certain forms of angina, or a recent history of heart attack or stroke.

clopidogrel

Plavix® Cardiology An antiplatelet agent that ↓ the risk of ischemic stroke, MI, and vascular death in Pts with prior cardiovascular disease Contraindications Active bleeding–eg, PUD, intracranial hemorrhage, or Pts at risk for bleeding due to trauma, surgery or other drug therapy Adverse events Dyspepsia, purpura, diarrhea, rash, intracranial hemorrhage, neutropenia. See CAPRIE. Cf Aspirin.

clopidogrel

A drug that acts mainly by inhibiting the ADP-mediated platelet aggregation pathway and has been shown to reduce mortality in patients with acute myocardial infarction. It usefully potentiates the action of aspirin. A brand name is Plavix.
References in periodicals archive ?
Patients in the observation group were given 600 mg of clopidogrel bisulfate tablets immediately after admission (national approval number: J20130083; Sanofi-Aventis (Hangzhou) Pharmaceutical Co., Ltd., China; specification: 75 mg/tablet; batch number: 3A579, 4A757, 5A458) and 300 mg of aspirin enteric-coated tablets.
Ticlopidine and clopidogrel block platelet activation by ADP and are considered to be marginally more effective than aspirin.
When stenting is used to prevent a heart attack, aspirin plus clopidogrel is the gold standard.
The researchers found that major ischemic events occurred in 5.0 and 6.5 percent of patients receiving clopidogrel plus aspirin versus aspirin plus placebo, respectively (hazard ratio, 0.75); most events occurred during the first week after the initial event.
As the use of clopidogrel has proliferated, hypersensitivity reactions have been increasingly recognized [7].
On discharge, the patient was started on multiple new medications including clopidogrel and atorvastatin.
SLNs containing clopidogrel were prepared by the high shear hot homogenization and ultrasound method following a standard procedure [14].
Entre esos agentes se encuentra el clopidogrel, el cual es un derivado estructural de la ticlopidina y tambien es un pro-farmaco.
However, some patients may suffer from attenuated platelets inhibition to clopidogrel or clopidogrel high on treatment platelets reactivity (HTPR) which hinders achieving the optimum outcome of DAPT.
Unfortunately, a significant minority of patients ([greater than or equal to] 35%) do not respond adequately to clopidogrel [16-25]; and a similar but lesser problem exists for aspirin [16, 18, 20, 26, 27].