The studies on GVHD treatment outcome will be pursued together with a detailed analysis of immune monitoring, comprising T cell receptor clonotype
tracking and tissue regeneration markers, in order to further understand the mechanisms underlying the therapeutic and regenerative potential of Treg cells.
In this case, identification of a single clonotype
as associated with the cancer allows for quantitative measurement of its reduction in response to treatment, ideally to undetectable levels.
Common T cell receptor clonotype
in lacrimal glands and labial salivary glands from patients with Sjogren's syndrome.
A fractal clonotype
distribution in the CD8 memory T cell repertoire could optimize potencial immune responses.
Primary development and participation in a foreign antigen-driven immune response of a chromatin-reactive B cell clonotype
are not influenced by TLR9 or other MyD88-dependent TLRs.
Carriage rates of methicillin-resistant Staphylococcus aureus (MRSA) depend on anatomic location, the number of sites cultured, culture methods, and the distribution of clonotypes
A total of 61 clonotypes
were established for the 133 isolates available for PFGE (Figure 2).
Ogata, "Preferential Expression of Variable Region Heavy Chain Gene Segments by Predominant 2,4-Dinitrophenyl-Specific Balb/C Neonatal Antibody Clonotypes
," Proceedings of the National Academy of Science USA 83, no.
The Figure, panel B, shows that CAMRSA identified during 1993-2002 consisted mainly of 3 clonotypes
(ST80, ST88, and ST5).
Sequencing of TCR clonotypes
from skin suggests an antigen driven response.
Characterisation of T cell clonotypes
that accumulated in multiple joints of patients with rheumatoid arthritis.
Chemokines are important mediators of leukocyte trafficking as well as the controlled recruitment of specific leukocyte clonotypes
required during host defense and inflammation.