clonality


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clonality

 [klo-nal´ĭ-te]
the ability to be cloned.

clonality

/clo·nal·i·ty/ (klo-nal´ĭ-te) the ability to be cloned.

clonality

A state of proliferation determined by the cell(s) of origin; daughter cells arising from multiple cells–ie polyclonal are reactive in nature, while those arising from a single cell–ie monoclonal are neoplastic; determining clonality is important in treating a disease, and understanding its physiopathology, and can be assessed in ♀ by molecular analysis of the patterns of X chromosome inactivation. See Clonal analysis.

clonality

the ability to form clones.
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References in periodicals archive ?
In contrast, the presence of a dominating DNA fragment indicative of clonality is illustrated by the patient samples in lanes 2, 3, and 4, which exhibit one or more densely stained bands in the 150- to 250-bp region and compare favorably with the positive controls in lanes 7 and 8.
We used a gold standard multiplex PCR protocol provided by European Biomedicine and Health (BIOMED-2) Concerted Action Project BMH4-CT98-3936 for improvement of diagnosis and analysis of clonality gene rearrangement in lymphoma malignancies.
However, additional sampling would seem unlikely to alter our basic conclusions, particularly with regard to the level of MLG diversity across the continental range and the extent of clonality within and among localities.
Optimization of PCR amplification for B-and T-cell clonality analysis on formalin-fixed and paraffin-embedded samples.
leprae might encode unique characteristics that could elicit the Lucio reaction is attractive and seems plausible, although highly speculative and challenging to prove, since genetic clonality and the absence of overt toxic affects in animal models seem to be major characteristics of M.
Safety will be determined by clinical and laboratory observation and grading of adverse events, analysis of T cell repertoire clonality, and evaluation of HIV isolates for evidence of vector recombination.
B-cell clonality studies for the presence of clonal IgH or Ig Kappa gene rearrangement would be useful in differentiating it from a plasmacytoma.
Nevertheless, determination of clonality is not usually necessary to establish a diagnosis of large-cell lymphoma while it is frequently necessary for lymphoproliferative disorders in which the cells are not morphologically abnormal such as chronic lymphocytic leukemia.
Sydes, MA and Peakall, R: Extensive clonality in the endangered shrub Haloragodendron lucasii (Haloragaceae) revealed by allozymes and RAPDs.