clonality


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clonality

 [klo-nal´ĭ-te]
the ability to be cloned.

clonality

A state of proliferation determined by the cell(s) of origin; daughter cells arising from multiple cells–ie polyclonal are reactive in nature, while those arising from a single cell–ie monoclonal are neoplastic; determining clonality is important in treating a disease, and understanding its physiopathology, and can be assessed in ♀ by molecular analysis of the patterns of X chromosome inactivation. See Clonal analysis.
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References in periodicals archive ?
Profiling clonality and progression in multiple premalignant and malignant oral lesions identifies a subgroup of cases with a distinct presentation of squamous cell carcinoma.
The authors associate triploidy advantage with unglaciated drought-prone regions where ecological factors favor clonality.
TCRp clonality improves diagnostic yield of TCRy clonality in refractory celiac disease.
The isolates were grouped in clones according to band patterns similarities (23), and the clonality was obtained by comparisons with previously published images (24).
To evaluate molecular clonality, three slices of 10p FFPE tissue were used for extraction of DNA according to the protocol previously described by Maria et al [13].
Following this is the hypothesis that there will be greater homozygosity and clonality in the interior compared to the edge of fragments.
We examined FoxP3+ Tregs in LN specimens from patients with MF/SS (including both involved and uninvolved LNs) and correlated the findings with clinical data, molecular assays for T-cell clonality, and flow cytometry.
To further characterize the [gamma] [delta] T-cell immune status in B-NHL, we investigated the distribution and clonality of TCR V[gamma] and V[delta] repertoire in peripheral blood (PB), bone marrow (BM), and lymph node (LN) from patients with B-NHL.
In natural populations of plant species, microsatellites have the potential to estimate genetic diversity and infer reproductive patterns (Morgante & Olivieri, 1993); i.e., inbreeding (Aldrich et al., 1998; Liu et al., 2003; Michalski & Durka, 2007), inter and intra-specific hybrids (Lexer et al., 2010), degree of clonality (Ainsworth et al., 2003).
Our patient was FlP1L1-PDGFRA-negative and did not show any evidence of T or B cell clonality. The diagnosis of idiopathic HES was considered after asthma, eczema, parasitic infestation, autoimmune disorders, and malignant neoplasm were ruled out.
Raychoudhuri et al., "Incidence, virulence factors, and clonality among clinical strains of non-O1, non-O139 Vibrio cholerae isolates from hospitalized diarrheal patients in Kolkata, India," Journal of Clinical Microbiology, vol.