clonal selection theory


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Related to clonal selection theory: clonal selection theory of immunity

clo·nal se·lec·tion the·o·ry

a theory which states that each lymphocyte has membrane-bound immunoglobulin receptors specific for a particular antigen and after the receptor is engaged, proliferation of the cell occurs such that a clone of antibody-producing cells (plasma cell) is produced.
Farlex Partner Medical Dictionary © Farlex 2012

clo·nal se·lec·tion the·or·y

(klō'năl sĕ-lek'shŭn thē'ŏr-ē)
A theory that states that each lymphocyte has membrane-bound immunoglobulin receptors specific for a particular antigen and after the receptor is engaged, proliferation of the cell occurs such that a clone of antibody producing cells (plasma cell) is produced.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Ultimately, the solution to the diversity question, and the identity of immunology's G.O.D., provided some insights into the development of self-nonself identity within the immune system, and a convincing confirmation of the clonal selection theory. By the late 1970s and early 1980s, the realization that antibody-producing cells were clonally selected focused attention on what was happening at the genetic level.
The examples from immunology and neurology (several of which-notably the clonal selection theory of the immune response-are returned to repeatedly with different methodological lessons in view) are dealt with in increasingly fascinating depth and in masterly fashion.