clonal restriction

clonal restriction

The occurrence of the same characteristics as the parent cell in all clones (offspring) of one B or T lymphocyte. For example, surface receptors are identical, so clones react to the same group of specific antigens as the parent cell does.
References in periodicals archive ?
Serum immunofixation electrophoresis (IFE), however, identified only a small clonal restriction in IgG while urine IFE identified a very tiny kappa restriction.
This problem is called "clonal restriction" and would make personalized stem cell therapy impractical.
This "clonal restriction" would make personalized stem cell therapy impractical.