Clonal restriction | definition of clonal restriction by Medical dictionary
The occurrence of the same characteristics as the parent cell in all clones (offspring) of one B or T lymphocyte. For example, surface receptors are identical, so clones react to the same group of specific antigens as the parent cell does.
References in periodicals archive
Serum immunofixation electrophoresis (IFE), however, identified only a small clonal restriction
in IgG while urine IFE identified a very tiny kappa restriction.
This problem is called "clonal restriction
" and would make personalized stem cell therapy impractical.
This "clonal restriction
" would make personalized stem cell therapy impractical.