in the absence of a clonal marker, no evidence that the bone marrow fibrosis or other changes are secondary to infection, autoimmune disorder or other chronic inflammatory condition, hairy cell leukemia or other lymphoid neoplasm, metastatic malignancy, or toxic myelopathies (1)
Demonstration of JAK2 V617F mutation or other clonal markers and no evidence of reactive thrombocytosis.
Demonstration of JAK2 V617F or other clonal marker
, or in the absence of JAK2 V617F, no evidence for reactive thrombocytosis.
Comparative analysis of T-cell receptor gene rearrangements at diagnosis and relapse of T-cell acute lymphoblastic leukemia (T-ALL) shows high stability of clonal markers
for monitoring of minimal residual disease and reveals the occurrence of second T-ALL.
The researchers use a technique called PCR to multiply this DNA to find more readily the tell-tale defects, known as clonal markers
, that indicate cancer.
Rearrangements of TCR genes in a rapidly proliferating neoplastic lymphoid cell population derived from a single progenitor cell are identical, involving unique combinations of specific variable (V), joining (J), diversity (D), and constant (C) gene segments, and thus serve as unique clonal markers
Urine free light chains in SLE: clonal markers
of B-cell activity and potential link to in vivo secreted Ig.
Genetic alterations as clonal markers
for bladder cancer detection in urine.