The number who had actually died from heart attacks was equal in both groups plus considerably more who had been treated with clofibrate
had died from other diseases.
Schade, "Effect of clofibrate
on arginine-stimulated glucagon and insulin secretion in man," Metabolism, vol.
SW480 cells were treated with PPAR[alpha] agonist (clofibrate
); the results showed that clofibrate
significantly increased autophagosome accumulation (Figure 5(a)).
Campbell et al., "Evaluation of the carcinogenic potential of clofibrate
in the FVB/Tg.AC mouse after oral administration--Part I," International Journal of Toxicology, vol.
Schaaf, "Comparison of clofibrate
and chlorpropamide in vasopressin-responsive diabetes insipidus," Metabolism: Clinical and Experimental, vol.
There are four classes of lipid-lowering drugs in the market: the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (the "statins"), the fibrates (gemfibrozil, clofibrate
, and fenofibrate), niacin/nicotinic acid, and the bile acid binding resins (colestipol and cholestyramine).
On the other hand, Lopid (gemfibrozil) and Atromid (clofibrate
) are reported to cause sleepiness.
Because some peroxisome proliferator activated-receptor alpha (PPAR[alpha]) activators are known to induce hepatocarcinogenesis in rodent liver, we investigated whether PPAR[alpha] activators (e.g., benziodarone, benzbromarone, fenofibrate, clofibrate
, ibuprofen, WY-14643, gemfibrozil) were randomly distributed across modules in RLV, PHH, and PRH.
is an activator of peroxisome proliferators-activated receptors (PPARS).
Fibrate medications include gemfibrozil (Lopid), fenofibrate (TriCor) and clofibrate
Linnainmaa, "Induction of sister chromatid exchanges by the peroxisome proliferators 2,4-D, MCPA, and clofibrate
in vivo and in vitro," Carcinogenesis, vol.
Peroxisome proliferation was first reported in rats treated with clofibrate
in the 1960s .