(redirected from clockwork)
Also found in: Dictionary, Thesaurus, Idioms, Encyclopedia, Wikipedia.
Related to clockwork: like clockwork


(klok) a device for measuring time.
biological clock  the physiologic mechanism which governs the rhythmic occurrence of certain biochemical, physiologic, and behavioral phenomena in living organisms.


1. An instrument other than a watch for measuring or indicating time, especially a mechanical or electronic device having a numbered dial and moving hands or a digital display.
2. A biological clock.
v. clocked, clocking, clocks
To register or record with a mechanical device: clocked the winds at 60 miles per hour.

clock′er n.


A gene on chromosome 4q12 that encodes a ubiquitously expressed human homolog of the mouse clock gene, which forms a heterodimer with ARNTL and activates E-box element transcription of several circadian clock proteins (e.g., PER1 and PER2). CLOCK is highly expressed in the suprachiasmatic nucleus.

Molecular pathology
CLOCK-ARNTL double mutations in the PAS domains result in syngernistic desensitisation to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1, disrupting circadian rhythmicity.


A device for measuring time.

biological clock

1. An internal system in organisms that influences behavior in a rhythmic manner. Functions such as growth, feeding, secretion of hormones, the rate of drug action, the wake-sleep cycle, the menstrual cycle, and reproduction coincide with certain external events such as day and night, the tides, and the seasons. Biological clocks appear to be set by environmental conditions in some animals, but if these animals are isolated from their environment they continue to function according to the usual rhythm. A gradual change in environment does produce a gradual change in the timing of the biological clock. See: circadian; maladaptation to night work; zeitgeber
2. A colloquial term for the decrease in fertility that accompanies aging, particularly as women approach the age of 35.

Patient discussion about clock

Q. How do you wake up in the morning if your narcolepsy is so severe you can't hear the alarm clock, phone ring? biggest problem is sleep paralysis, can't wake up. Late for work, everything, life is suffering because of severity. Have tried ritalin, natural supplements, hypnosis therapy, Provigal, antidepressants, nothing seems to work. Employer thinks it's an excuse, friends are irritated, I'm at my wits end. Life is spent sleeping more than awake.

A. Narcolepsy cannot yet be cured. But EDS and cataplexy, the most disabling symptoms of the disorder, can be controlled in most patients with drug treatment. Often the treatment regimen is modified as symptoms change. For decades, doctors have used central nervous system stimulants-amphetamines such as methylphenidate, dextroamphetamine, methamphetamine, and pemoline-to alleviate EDS and reduce the incidence of sleep attacks. For most patients these medications are generally quite effective at reducing daytime drowsiness and improving levels of alertness. However, they are associated with a wide array of undesirable side effects so their use must be carefully monitored. Common side effects include irritability and nervousness, shakiness, disturbances in heart rhythm, stomach upset, nighttime sleep disruption, and anorexia. For full article: Hope this helps.

More discussions about clock
References in periodicals archive ?
Carl Haagenson of NatWest with Peter Southern and Melissa Beckett of Clockwork Espresso
Looking to build on their impressive client base that includes Hobbycraft, La Redoute, TravelZoo and Newcastle based Weekend Box Clockwork Affiliates are expanding with the recent addition of a new apprentice and a focus on helping e-commerce sites make the most of the affiliate sector.
The two girls and one boy have since returned home from hospital but with Clockwork Orange showing similarities to substances like Black Mamba and Mexxy - which were banned and made Class B drugs in February - experts have said "just because something is legal, that does not make it safe".
We hope to meet the same standards of performance par excellence in this play that has become synonymous with Clockwork Productions due to our previous stage plays.
A CLOCKWORK Orange is at The Unity on Friday and Saturday.
THE gloomy Clockwork Orange music that welcomed White Lies to the stage jarred with the joyous reception they got from the crowd.
Both properties are fully leased by Clockwork Learning Centers, a private childhood education organization.
UK utility group Centrica plc (LSE:CNA) reported on Thursday that its North American subsidiary, Direct Energy, has agreed to acquire the assets of home services business Clockwork Home Services Inc.
Tunnel's Mike Walsh said: "We've done a special festival ale called Clockwork Orange.
Tom is an apprentice toymaker who loses his job when his interest in making clockwork toys is not appreciated by his master.
THOSE Scouse rockers CLOCKWORK will headline tonight's Shine Like Stars gig at the Ku Bar in Stockton.