clock

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clock

(klok) a device for measuring time.
biological clock  the physiologic mechanism which governs the rhythmic occurrence of certain biochemical, physiologic, and behavioral phenomena in living organisms.

clock

(klŏk)
n.
1. An instrument other than a watch for measuring or indicating time, especially a mechanical or electronic device having a numbered dial and moving hands or a digital display.
2. A biological clock.
v. clocked, clocking, clocks
v.tr.
To register or record with a mechanical device: clocked the winds at 60 miles per hour.

clock′er n.

CLOCK

A gene on chromosome 4q12 that encodes a ubiquitously expressed human homolog of the mouse clock gene, which forms a heterodimer with ARNTL and activates E-box element transcription of several circadian clock proteins (e.g., PER1 and PER2). CLOCK is highly expressed in the suprachiasmatic nucleus.

Molecular pathology
CLOCK-ARNTL double mutations in the PAS domains result in syngernistic desensitisation to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1, disrupting circadian rhythmicity.

clock

(klok)
A device for measuring time.

biological clock

1. An internal system in organisms that influences behavior in a rhythmic manner. Functions such as growth, feeding, secretion of hormones, the rate of drug action, the wake-sleep cycle, the menstrual cycle, and reproduction coincide with certain external events such as day and night, the tides, and the seasons. Biological clocks appear to be set by environmental conditions in some animals, but if these animals are isolated from their environment they continue to function according to the usual rhythm. A gradual change in environment does produce a gradual change in the timing of the biological clock. See: circadian; maladaptation to night work; zeitgeber
2. A colloquial term for the decrease in fertility that accompanies aging, particularly as women approach the age of 35.

Patient discussion about clock

Q. How do you wake up in the morning if your narcolepsy is so severe you can't hear the alarm clock, phone ring? biggest problem is sleep paralysis, can't wake up. Late for work, everything, life is suffering because of severity. Have tried ritalin, natural supplements, hypnosis therapy, Provigal, antidepressants, nothing seems to work. Employer thinks it's an excuse, friends are irritated, I'm at my wits end. Life is spent sleeping more than awake.

A. Narcolepsy cannot yet be cured. But EDS and cataplexy, the most disabling symptoms of the disorder, can be controlled in most patients with drug treatment. Often the treatment regimen is modified as symptoms change. For decades, doctors have used central nervous system stimulants-amphetamines such as methylphenidate, dextroamphetamine, methamphetamine, and pemoline-to alleviate EDS and reduce the incidence of sleep attacks. For most patients these medications are generally quite effective at reducing daytime drowsiness and improving levels of alertness. However, they are associated with a wide array of undesirable side effects so their use must be carefully monitored. Common side effects include irritability and nervousness, shakiness, disturbances in heart rhythm, stomach upset, nighttime sleep disruption, and anorexia. For full article: http://www.ninds.nih.gov/disorders/narcolepsy/detail_narcolepsy.htm#120393201 Hope this helps.

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References in periodicals archive ?
In this method, the revolution of the planet wheel axis or pin through 360 deg in a clockwise direction is taken to be the reference basis for the analysis.
The clockwise and anti-clockwise link roads to the M4 eastbound will be closed overnight, between 10pm and 5am, on Monday 28 September.
The drive across the circle begins with the lower body leading the throw in a sweeping soccer kicking motion with the inside of the right thigh (ahead of the trunk) turning counter-clockwise, and the upper body turning clockwise.
We are very happy to see ClockWise endorsed by a fast growing company like Sunplus and having ClockWise widely adopted throughout Sunplus' advanced design flow methodology," remarked Bob Xu, VP of International Sales and Operations of Celestry.
The southbound link road to the M25 clockwise will be closed overnight, between 10pm and 5am, on Monday 21 September.
CLOCKWISE FROM TOP LEFT: Pink floral head dress, pounds 15, M&S; Shiny bobbles, pounds 2 per pack, M&S; Aqua floral band, pounds 3.
Golden Globe nominations went to, clockwise from top right:
In clockwise rotation, the flagella come apart and the bacterium tumbles head over heel, reorienting its swimming direction (SN:5/12/84, p.
The existing tree optimization feature in ClockWise was superb in performing both pre-route and post-route skew optimization.
Motors Consisting Of One In Each Of Clockwise Anti Clockwise Rotation For Ac Coaches As Per Icf Specification No.
All traffic from Foleshill Road would filter on clockwise and those wishing to go anti-clockwise would go round at J2 - a short diversion.
Then on Page 3-21 it shows the rotation as right; side clockwise and left; side counterclockwise.