clock

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clock

(klŏk)
n.
1. An instrument other than a watch for measuring or indicating time, especially a mechanical or electronic device having a numbered dial and moving hands or a digital display.
2. A biological clock.
v. clocked, clocking, clocks
v.tr.
To register or record with a mechanical device: clocked the winds at 60 miles per hour.

clock′er n.

CLOCK

A gene on chromosome 4q12 that encodes a ubiquitously expressed human homolog of the mouse clock gene, which forms a heterodimer with ARNTL and activates E-box element transcription of several circadian clock proteins (e.g., PER1 and PER2). CLOCK is highly expressed in the suprachiasmatic nucleus.

Molecular pathology
CLOCK-ARNTL double mutations in the PAS domains result in syngernistic desensitisation to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1, disrupting circadian rhythmicity.

clock

(klok)
A device for measuring time.

biological clock

1. An internal system in organisms that influences behavior in a rhythmic manner. Functions such as growth, feeding, secretion of hormones, the rate of drug action, the wake-sleep cycle, the menstrual cycle, and reproduction coincide with certain external events such as day and night, the tides, and the seasons. Biological clocks appear to be set by environmental conditions in some animals, but if these animals are isolated from their environment they continue to function according to the usual rhythm. A gradual change in environment does produce a gradual change in the timing of the biological clock. See: circadian; maladaptation to night work; zeitgeber
2. A colloquial term for the decrease in fertility that accompanies aging, particularly as women approach the age of 35.

Patient discussion about clock

Q. How do you wake up in the morning if your narcolepsy is so severe you can't hear the alarm clock, phone ring? biggest problem is sleep paralysis, can't wake up. Late for work, everything, life is suffering because of severity. Have tried ritalin, natural supplements, hypnosis therapy, Provigal, antidepressants, nothing seems to work. Employer thinks it's an excuse, friends are irritated, I'm at my wits end. Life is spent sleeping more than awake.

A. Narcolepsy cannot yet be cured. But EDS and cataplexy, the most disabling symptoms of the disorder, can be controlled in most patients with drug treatment. Often the treatment regimen is modified as symptoms change. For decades, doctors have used central nervous system stimulants-amphetamines such as methylphenidate, dextroamphetamine, methamphetamine, and pemoline-to alleviate EDS and reduce the incidence of sleep attacks. For most patients these medications are generally quite effective at reducing daytime drowsiness and improving levels of alertness. However, they are associated with a wide array of undesirable side effects so their use must be carefully monitored. Common side effects include irritability and nervousness, shakiness, disturbances in heart rhythm, stomach upset, nighttime sleep disruption, and anorexia. For full article: http://www.ninds.nih.gov/disorders/narcolepsy/detail_narcolepsy.htm#120393201 Hope this helps.

More discussions about clock
References in classic literature ?
And as Prince Michael's eye rested upon the glowing face of the great clock in the tower, his smile, altruistic as it was, became slightly tinged with contempt.
For half an hour he smoked cigars with nervous haste, and then he fell to watching the face of the illuminated clock above the trees.
The young man glanced at the clock again and frowned darkly.
Well, at 6 o'clock I stood in that house with the young lady I am-- that is, I was--engaged to.
If you see no scarf you may consider that everything between us is ended forever.' That," concluded the young man bitterly, "is why I have been watching that clock. The time for the signal to appear has passed twenty- three minutes ago.
Sonorous and startling came the stroke of 9 from the clock tower.
And then, from habit, he glanced at the clock in the tower, and made further oration.
It was evident, however, that just at this moment the fellow in the steeple was doing something that he had no business to do with the clock. But as it now began to strike, nobody had any time to attend to his manoeuvres, for they had all to count the strokes of the bell as it sounded.
de Treville, looking at the clock; "why, that's impossible!"
"Look, rather, monsieur," said D'Artagnan, "the clock shows it."
Clocks have always played an extremely important role in every human being's life.
Wake-Up Light Alarm Clocks sit on your bedside table like an alarm clock, but instead of rousing you with sound, they rely on light to ease you awake gradually over about 30 minutes.