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(klok) a device for measuring time.
biological clock  the physiologic mechanism which governs the rhythmic occurrence of certain biochemical, physiologic, and behavioral phenomena in living organisms.


1. An instrument other than a watch for measuring or indicating time, especially a mechanical or electronic device having a numbered dial and moving hands or a digital display.
2. A biological clock.
v. clocked, clocking, clocks
To register or record with a mechanical device: clocked the winds at 60 miles per hour.

clock′er n.


A gene on chromosome 4q12 that encodes a ubiquitously expressed human homolog of the mouse clock gene, which forms a heterodimer with ARNTL and activates E-box element transcription of several circadian clock proteins (e.g., PER1 and PER2). CLOCK is highly expressed in the suprachiasmatic nucleus.

Molecular pathology
CLOCK-ARNTL double mutations in the PAS domains result in syngernistic desensitisation to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1, disrupting circadian rhythmicity.


A device for measuring time.

biological clock

1. An internal system in organisms that influences behavior in a rhythmic manner. Functions such as growth, feeding, secretion of hormones, the rate of drug action, the wake-sleep cycle, the menstrual cycle, and reproduction coincide with certain external events such as day and night, the tides, and the seasons. Biological clocks appear to be set by environmental conditions in some animals, but if these animals are isolated from their environment they continue to function according to the usual rhythm. A gradual change in environment does produce a gradual change in the timing of the biological clock. See: circadian; maladaptation to night work; zeitgeber
2. A colloquial term for the decrease in fertility that accompanies aging, particularly as women approach the age of 35.

Patient discussion about clock

Q. How do you wake up in the morning if your narcolepsy is so severe you can't hear the alarm clock, phone ring? biggest problem is sleep paralysis, can't wake up. Late for work, everything, life is suffering because of severity. Have tried ritalin, natural supplements, hypnosis therapy, Provigal, antidepressants, nothing seems to work. Employer thinks it's an excuse, friends are irritated, I'm at my wits end. Life is spent sleeping more than awake.

A. Narcolepsy cannot yet be cured. But EDS and cataplexy, the most disabling symptoms of the disorder, can be controlled in most patients with drug treatment. Often the treatment regimen is modified as symptoms change. For decades, doctors have used central nervous system stimulants-amphetamines such as methylphenidate, dextroamphetamine, methamphetamine, and pemoline-to alleviate EDS and reduce the incidence of sleep attacks. For most patients these medications are generally quite effective at reducing daytime drowsiness and improving levels of alertness. However, they are associated with a wide array of undesirable side effects so their use must be carefully monitored. Common side effects include irritability and nervousness, shakiness, disturbances in heart rhythm, stomach upset, nighttime sleep disruption, and anorexia. For full article: Hope this helps.

More discussions about clock
References in periodicals archive ?
For its plot to make any sense, Clockers has to build up a feeling of inevitability.
In the closing scene of Spike Lee's Clockers (1995), Strike Dunham--the film's young, ulcer-prone protagonist--escapes from the life-threatening dangers of urban life.
Clockers are using computers to change the mileage on new digital speedometers.
Ryan Murphy's goal off a two-on-one break at 12:57 gave the Clockers a 1-0 lead.
But perhaps the turning point in this one came 25 seconds into the second period, when defenseman Ryan Menard was able to poke in a rebound off the pad of goalie Kevin Miller while the Clockers skated five-on-three.
Price and Pelecanos are also accomplished novelists; Price is most famous for Freedomland and Clockers , but has also received critical acclaim for novels like Lush Life .
Yet, the problem is now more prevalent than ever with the electronics that were intended to stop the clockers helping them to disguise their tracks better than ever.
The Rockets dropped a 61-36 decision to the Clockers last month.
Indeed, Richard Wright's Native Son (1940) and Ernest Gaines's A Lesson Before Dying (1993), or Spike Lee's Clockers (1995), highlight the glaring absence of works that depict the attempts of African Americans to navigate the hegemonic forces that frequently trap black men in the criminal justice system.
He further added, "This product will be positioned for high end workstations, Research centers, Corporates, Tech Enthusiasts, High end Gamers and Over Clockers.
While this first novel is not without flaws (Macu is never developed beyond an alluring memory), it is bound to appeal to fans of Roddy Doyle's Commitments, Carson McCullers' Ballad of the Sad Cafe, and Richard Price's Clockers.