In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma
or cloacogenic adenocarcinoma .
The onset of symptoms is often abrupt, with the duration of symptoms for cloacogenic carcinoma being generally shorter in comparison to those for squamous cell anal neoplasms .
One small study of anal cloacogenic carcinoma found that 5FU plus MMC or cisplatin led to three- and five-year survival rates of 71% and 48%, respectively .
Seigler, "Cloacogenic carcinoma," Annals of Surgery, vol.
Souilliard, "Transitional cloacogenic carcinoma of the anal canal.
of the anorectum in homosexual men: an observation of four cases.
Cloacogenic carcinoma arise from the mucosa of transitional or cloacogenic zone separating the rectal and anal mucous membranes.
Diagnosis--Features are consistent with cloacogenic carcinoma.
(2.) Fisher ER: The basal cell nature of the so-called transitional cloacogenic carcinoma of anus as revealed by electron microscopy.
The morphologic patterns that are commonly associated with basaloid or cloacogenic carcinoma include nested and trabecular growth of small cells without the intercellular bridges typical of conventional squamous cell carcinoma (Figure 4), although foci of more conventional squamous differentiation can usually be found.
Histogenesis of cloacogenic carcinoma: fine structure of anal transitional epithelium and cloacogenic carcinoma.
In addition, the possibility of a metastatic cloacogenic carcinoma
of the anus and adenoid cystic/basal cell carcinoma arising in Cowper glands should be also addressed.