Clinical Assessment: In isolated cryptorchidism, a chromosomal anomaly may be present in approximately 3% cases, in hypospadias 7% and in a combination of cryptorchidism and hypospadias, in 13% cases.13 In infants with proximal hypospadias (penoscrotal, scrotal, perineal), detailed studies performed revealed a likely cause in 31% of cases.14 Infants with suspected DSD who require further clinical evaluation should include those with isolated perineal hypospadias, isolated micropenis, isolated
clitoromegaly, any form of familial hypospadias and those who have a combination of genital anomalies with an external masculinisation score (EMS) of<11.15
Testosterone Levels in Newborns with
Clitoromegaly in Central Brooklyn.
(41,42) More than half of the patients experience androgenic hormonal manifestations: hirsutism,
clitoromegaly, and amenorrhea.
Such cysts can cause
clitoromegaly and can be described as ambiguous genitalia when present at birth (19).
The spectrum of female phenotype can vary from normal female to female with
clitoromegaly to men with hypospadias, bifid scrotum, or micropenis to occasional phenotypically normal male.
apparent female genitalia with
clitoromegaly, posterior labial fusion or inguinal/labial mass and apparent male genitalia with non-palpable testes), micropenis, undescended testis (testes presenting as inguinal hernia or abdominal testes found on imaging studies), incomplete or delayed puberty and primary amenorrhea.
She was anxious and overweight (BMI: 38.06) with enlarged thyroid gland,
clitoromegaly, male pattern baldness (significant loss of scalp hair) and hirsutism.
Tsuboi et al., "Microscope-assisted reduction clitoroplasty used to treat two patients with
clitoromegaly," Journal of Nippon Medical School, vol.
Physical exam revealed virilization and
clitoromegaly but it was otherwise noncontributory.
She had normal genitalia without
clitoromegaly, labial fusion, or hyperpigmentation and no palpable abdominal mass.
Nicita, "Hemangioma of the clitoris presenting as
clitoromegaly: a case report," Journal of Pediatric and Adolescent Gynecology, vol.
For postpubertal females in whom polycystic ovary syndrome (PCOS) or other hyperandrogenic states are suspected, hormonal testing is indicated in the presence of the clinical signs of infrequent menses and infertility, hirsutism, truncal obesity, androgenetic alopecia, polycystic ovaries, or
clitoromegaly.
