Frederickson et al., "Clioquinol
effects on tissue chelatable zinc in mice," Journal of Molecular Medicine, vol.
Zhu et al., "The antiparasitic clioquinol
induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity," The Journal of Biological Chemistry, vol.
R., 2006, "Determination of 5-chloro-7-iodo-8-quinolinol (clioquinol
) in plasma and tissues of hamsters by high-performance liquid chromatography and electrochemical detection, " J.
attenuates zinc-dependent beta-cell death and the onset of insulitis and hyperglycemia associated with experimental type I diabetes in mice.
Recent animal studies have shown that the drug, clioquinol
, can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases.
Oral treatment of transgenic mouse with clioquinol
resulted in halving of A[beta] levels and significantly increased the levels of Cu and Zn in the brain (72).
Indeed, clinical trials are currently in progress to ascertain the potential therapeutic value of metal chelators (e.g deferoxamine, deferiprone, clioquinol
) and high-dose antioxidants (e.g.
fue una droga fabricada en los anos 70 y vendida como un remedio seguro para la diarrea.
has received approval from the Medicines and Healthcare Products Regulatory Agency in the United Kingdom to begin a phase II/phase III study of clioquinol
, also known as PBT-1.
Prana Biotechnology Limited has announced that it will not proceed with supporting the initiation of the PLACQUE study evaluating PBT1 (clioquinol
) for Alzheimer's disease and has re-evaluated any further work on the PBT1 program.
Both folate and vitamin [B.sub.12] were administered to all patients to counteract an observed association between oral clioquinol
and myelooptico-neuropathy that led to the drug's withdrawal from sale in 1970.
Your treatment depends on the cause, but vioform-hydrocortisone cream (hydrocortisone 1 per cent, clioquinol
3 per cent) will reduce the redness and soreness and treat any infection.