Serum IgG repertoire in clinically isolated syndrome
predicts multiple sclerosis.
Does self-efficacy affect cognitive performance in persons with clinically isolated syndrome
and early relapsing remitting multiple sclerosis?
Audoin et al., "Early cognitive impairment in patients with clinically isolated syndrome
suggestive of multiple sclerosis," Multiple Sclerosis, vol.
Pelletier, "Connecting white matter injury and thalamic atrophy in clinically isolated syndromes
," Journal of the Neurological Sciences, vol.
Indeed, optic neuritis can be the initial presentation as a clinically isolated syndrome
in patients who subsequently are diagnosed with MS (Figure 13).
This is known as a clinically isolated syndrome
. Not everyone who experiences a clinically isolated syndrome
goes on to develop MS.
We included subjects with clinically isolated syndrome
if they fulfilled two or more modified Barkhof MRI criteria .
* Researchers at the University of California-San Francisco identified a pattern of gene expression within immune cells that was associated with quick conversion to MS in a study of 37 people with CIS (clinically isolated syndrome
Patients with such presentations who have not had a recent stroke or show no other identifiable cause are diagnosed with clinically isolated syndrome
Participants in this trial had CIS, or clinically isolated syndrome
, meaning they had each had a single demyelinating event, but had not been diagnosed with MS.
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system affecting 2.3 million people worldwide[ii] with females more impacted than males.[iii] The disease is characterized by demyelination1and axonal loss leading to neurological impairment and severe disability.[iv] The main subtype of MS is relapsing forms of MS (RMS), which represents 85% of MS patients and includes clinically isolated syndrome
(CIS), relapsing-remitting MS (RRMS) and active secondary progressive MS (SPMS).[v]
TDLs in clinically isolated syndrome
(CIS) and MS cases typically occur during the first demyelinating attack in most patients.