clinical specificity

clin·i·cal spec·i·fi·ci·ty

(klin'i-kăl spes'i-fis'i-tē)

The frequency of negative results in patients without the disease (true-negative results).

References in periodicals archive ?

In addition, the assay must have a high clinical specificity to rule out those patients who do not have DVT or PE.

D-dimer utilization for the diagnosis of venous thromboembolism

1) and a previous study (3) has been shown to have a very high clinical specificity.

Anabasine Is a Poor Marker for Determining Smoking Status of Transplant Patients

Clinical sensitivity, clinical specificity, positive predictive value, and negative predictive value were calculated with the conventional contingency tables, and 95% confidence intervals (95% CI) were computed using the exact binomial method.

Clinical Validation of Anyplex II HPV HR Detection Test for Cervical Cancer Screening in Korea

As expected, the absolute clinical specificity for CIN2+/CIN3+ varied greatly across studies due to the heterogeneous nature of the referral populations (Table 1).

The abbott realtime high risk HPV test is a clinically validated human papillomavirus assay for triage in the referral population and use in primary cervical cancer screening in women 30 years and older: a review of validation studies

Constructivist therapy often gets labeled as too theoretical and lacking in clinical specificity.

Preface

Analytical and clinical specificity can also be impacted by aspects such as sample collection, storage and stability.

Biomarkers in drug development: a product development perspective: Andrew Roche, scientific director of Dublin-based life scientific, details aspects for consideration in the design, development and validation of assays for the evaluation of both protein and nucleic acid based biomarkers

There also is a lack of EEG and clinical specificity to associate epileptic encephalography with autistic regression, because most children with autistic regression on overnight EEG testing do not have epileptiform activity and there is no clinical difference between children with autistic regression and those with nonregressive ASD.

Epileptic encephalopathy: regression is selective

Numerous studies have demonstrated that the mRNA-based hrHPV assay has higher clinical specificity for detection of cervical cancer lesions than DNA-based hrHPV assays (8,10) (Figure 1).

mRNA-based hrHPV assay in cotesting for cervical cancer screening

Although EIA demonstrated good clinical specificity (ie, few positive results among patients with low likelihood of disease), it was not especially useful for detecting patients with high disease probability (suggesting low clinical sensitivity).

Comparison of analytical and clinical performance of three methods for detection of Clostridium difficile

Given that lipase remains increased for longer periods of time and has higher clinical specificity, as Dr.

Readers respond: further insight on amylase and lipase

The cutoff concentration for the Bayer ADVIA Centaur assay was set at 100 ng/L to maximize clinical specificity (>97%) and to be greater than the upper confidence limit of the 95th percentile of the non-HF reference population.

Analytical and clinical evaluation of the Bayer ADVIA centaur automated B-Type natriuretic peptide assay in patients with heart failure: a multisite study