Initially, cardiac troponin T (cTnT) was introduced, but there were questions related to its clinical specificity
. These questions subsequently were found to result from antibody cross-reactivity with skeletal muscle troponin, and that problem was thought to have been resolved (2).
As current solid-phase immunoassays have variable performances due to lack of standardization , CLIFT is often regarded as a reference method, owing to its high clinical specificity
and the omission of radioactive labeling in contrast to the Farr assay.
Thus, it is difficult to discriminate IAC from biliary duct malignancy merely from clinical manifestation and preoperative MRCP findings because of the low clinical specificity
and occasionally elevated tumor markers.
In addition, the assay must have a high clinical specificity
to rule out those patients who do not have DVT or PE.
The clinical sensitivity, clinical specificity
, positive predictive value, and negative predictive value of the HPV HR and HC2 are shown in Tables 3 and 4.
The study also included 80 serum samples from a control group to determine the clinical specificity
of both tests.
As expected, the absolute clinical specificity
for CIN2+/CIN3+ varied greatly across studies due to the heterogeneous nature of the referral populations (Table 1).
In 2010 this has now been achieved although the increased sensitivity has come at a cost of decreased clinical specificity
. To guard against over-diagnosis of Ml, the definition requires a rise or fall in biomarker level to be documented although did not specify the degree of change needed to satisfy the diagnosis.
Constructivist therapy often gets labeled as too theoretical and lacking in clinical specificity
. Yet here is a volume that counters that with chapters that succinctly and understandably explicate basic theoretical concepts and then demonstrate them with vivid case examples taken from applied experience in the field.
Analytical and clinical specificity
can also be impacted by aspects such as sample collection, storage and stability.
There also is a lack of EEG and clinical specificity
to associate epileptic encephalography with autistic regression, because most children with autistic regression on overnight EEG testing do not have epileptiform activity and there is no clinical difference between children with autistic regression and those with nonregressive ASD.
For its part, Riverside executives understand the depth of their commitment and the clinical specificity
which they have assigned to an HIS installation.