clinical findings

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diabetes mellitus

Endocrinology A chronic condition which affects ±10% of the general population, characterized by ↑ serum glucose and a relative or absolute ↓ in pancreatic insulin production, or ↓ tissue responsiveness to insulin; if not properly controlled, the excess glucose damages blood vessels of the eyes, kidneys, nerves, heart Types Insulin dependent–type I and non-insulin dependent–type II diabetes Symptoms type 1 DM is associated with ↑ urine output, thirst, fatigue, and weight loss (despite an ↑ appetite), N&V; type 2 DM is associated with, in addition, non-healing ulcers, oral and bladder infections, blurred vision, paresthesias in the hands and feet, and itching Cardiovascular MI, stoke Eyes Retinal damage, blindness Legs/feet Nonhealing ulcers, cuts leading to gangrene and amputation Kidneys HTN, renal failure Neurology Paresthesias, neuropathy Diagnosis Serum glucose above cut-off points after meals or when fasting; once therapy is begun, serum levels of glycosylated Hb are measured periodically to assess adequacy of glucose control Management Therapy reflects type of DM; metformin and triglitazone have equal and additive effects on glycemic control Prognosis A function of stringency of glucose control and presence of complications. See ABCD Trial, Brittle diabetes, Bronze diabetes, Chemical diabetes, Gestational diabetes, Insulin-dependent diabetes, Metformin, MODY diabetes, Nephrogenic diabetes insipidus, Non-insulin-dependent diabetes mellitus, Pseudodiabetes, Secondary diabetes, Starvation diabetes, Troglitazone.
Diabetes mellitus–Type 1 vs Type 2
Finding Type 1 Type 2
% of diabetics  10%  90%
Age of onset Usually < 35  Usually > 40
Weight Not overweight Overweight
Speed of onset Often abrupt/acute Asymptomatic, slower onset
Clinical findings ↑ Thirst, urine production Poorly healing cuts, paresthesias
 appetite; rapid weight loss of hands/feet; recurring skin, oral,
 fatigue  infections
Lab findings Ketonuria

clinical findings

reported symptoms, objective signs and disease prognosis
References in periodicals archive ?
Patients with COPD who complain of dyspnea should be assessed for the four clinical findings to help determine whether their dyspnea is related to COPD or could be a component of HF so that they can be treated appropriately.
However, clinical findings are reported elsewhere (1), in particular, details of management of neurologic, respiratory, and cardiac complications of these diseases.
Clinical findings become extremely important in differentiating the two, according to Dr.
Findings suggest those patients who do not have clinical findings above can proceed to immediate lumbar puncture, potentially decreasing CT scan frequency by 41%.
The SPECT reading should be done by an expert and combined with clinical findings and neuropsychological results to achieve an accurate diagnosis.
Clinical findings may include dark-colored urine, swelling of different parts of the body (edema), and high blood pressure.
Both of these clinical findings were statistically significant.
Schaefer of Tufts University in Boston agrees that medication may indeed influence clinical findings.
This report provides a comprehensive review of 27 candidate therapeutic antibodies and 42 candidate vaccines that are being evaluated for the treatment of lung cancer, covering pipeline, disease-targeting strategies and clinical findings.
The maps are followed by a color atlas of tickborne diseases with plates depicting typical skin lesions and other clinical findings along with examples of microscopic pathology.
Based on the current clinical findings, we believe Clevudine has the potential to be a key component of future combination therapy for chronic HBV.
Facial nerve hemangiomas and facial nerve neuromas yield similar clinical findings.

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