clinical findings

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diabetes mellitus

Endocrinology A chronic condition which affects ±10% of the general population, characterized by ↑ serum glucose and a relative or absolute ↓ in pancreatic insulin production, or ↓ tissue responsiveness to insulin; if not properly controlled, the excess glucose damages blood vessels of the eyes, kidneys, nerves, heart Types Insulin dependent–type I and non-insulin dependent–type II diabetes Symptoms type 1 DM is associated with ↑ urine output, thirst, fatigue, and weight loss (despite an ↑ appetite), N&V; type 2 DM is associated with, in addition, non-healing ulcers, oral and bladder infections, blurred vision, paresthesias in the hands and feet, and itching Cardiovascular MI, stoke Eyes Retinal damage, blindness Legs/feet Nonhealing ulcers, cuts leading to gangrene and amputation Kidneys HTN, renal failure Neurology Paresthesias, neuropathy Diagnosis Serum glucose above cut-off points after meals or when fasting; once therapy is begun, serum levels of glycosylated Hb are measured periodically to assess adequacy of glucose control Management Therapy reflects type of DM; metformin and triglitazone have equal and additive effects on glycemic control Prognosis A function of stringency of glucose control and presence of complications. See ABCD Trial, Brittle diabetes, Bronze diabetes, Chemical diabetes, Gestational diabetes, Insulin-dependent diabetes, Metformin, MODY diabetes, Nephrogenic diabetes insipidus, Non-insulin-dependent diabetes mellitus, Pseudodiabetes, Secondary diabetes, Starvation diabetes, Troglitazone.
Diabetes mellitus–Type 1 vs Type 2
Finding Type 1 Type 2
% of diabetics  10%  90%
Age of onset Usually < 35  Usually > 40
Weight Not overweight Overweight
Speed of onset Often abrupt/acute Asymptomatic, slower onset
Clinical findings ↑ Thirst, urine production Poorly healing cuts, paresthesias
 appetite; rapid weight loss of hands/feet; recurring skin, oral,
 fatigue  infections
Lab findings Ketonuria
References in periodicals archive ?
Recommended diagnostic criteria for central and peripheral nervous system neurosarcoidosis are divided into three groups as possible, probable and definite Recommended diagnostic criteria for central and peripheral nervous system neurosarcoidosis Possible - Clinical findings and MRI, CSF, and EMG findings are compatible with granulomatous inflammation of the nervous system and other causes are excluded by detailed investigations.
It is an example in terms of clinically encountered patients because it carries typical clinical findings.
However, in patients who have celiac disease and do not receive any treatment, it has been reported in recent years that invagination is seen as a rare clinical finding of the disease (3).
Infants without clinical findings, whose mothers have lab-confirmed Zika exposure
Discussion focused on the diagnosis, evaluation, and management of three groups of infants born to mothers with possible Zika virus exposure during pregnancy: 1) infants with clinical findings consistent with congenital Zika syndrome, regardless of maternal testing results, 2) infants without clinical findings consistent with congenital Zika syndrome who were born to mothers with laboratory evidence of possible Zika virus infection, and 3) infants without clinical findings consistent with congenital Zika syndrome who were born to mothers without laboratory evidence of possible Zika virus infection (Figure).
Clinical findings and symptom reports are instruments of differing nature, considering that the clinical examination is performed by the evaluator by means of provocative tests, while the reporting of symptoms is the result of the individual's perception.
Paranasal sinus mucoceles cause clinical findings by compressing the surrounding adjacent structures, especially the orbits and cranial or facial structures through expansion.
Atypical antipsychotic exposure did not cause fewer clinical findings than that of typical antipsychotics.
Patient particulars, brief history and clinical findings, provisional diagnosis and differential diagnosis (if any) were clearly mentioned in the biopsy requisition form.
Symptoms and clinical findings are similar so clinical evaluation is inadequate in differential diagnosis.1,2
The three appendixes at the end include differential diagnosis tem-plates, clinical findings templates, and a bibliography.
Ambry associated director of Clinical Genomics, Sha Tang, commented that the clinical findings back a 39% detection rate in patients tested with diagnostic exome sequencing in the company's lab.

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