clindamycin


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Related to clindamycin: metronidazole, Clindamycin phosphate

clindamycin

 [klin″dah-mi´sin]
1. a semisynthetic antibiotic that is a derivative of lincomycin; used to treat gram-positive penicillin-resistant infections.
2. a semisynthetic derivative of lincomycin used systemically, topically, and vaginally as an antibacterial, primarily against gram-positive bacteria; used also as the hydrochloride and phosphate salts and as the hydrochloride salt of the ester of clindamycin and palmitic acid (clindamycin palmitate hydrochloride).

clindamycin

/clin·da·my·cin/ (klin″dah-mi´sin) a semisynthetic derivative of lincomycin used systemically, topically, and vaginally as an antibacterial, primarily against gram-positive bacteria; used also as the hydrochloride and phosphate salts and as the hydrochloride salt of the ester of clindamycin and palmitic acid.

clindamycin

(klĭn′də-mī′sĭn)
n.
A semisynthetic antibiotic, C18H33ClN2O5S, derived from lincomycin and active against gram-positive bacteria.

clindamycin

Infectious disease An antibiotic combined with pyrimethamine to treat and prevent toxoplasmosis, PCP and, topically, for acne vulgaris Adverse effects Diarrhea, dysgeusia. See AIDS.

clindamycin

An antibiotic drug that penetrates well into bone to treat OSTEOMYELITIS. The drug is on the WHO official list. Brand names are Dalacin C and, for external use, Dalacin T.

clindamycin

macrolide; antibiotic agent effective against Gram-positive cocci, penicillin-resistant staphylococci (e.g. meticillin-resistant Staphylococcus aureus [MRSA]) and anaerobes; used to treat osteomyelitis and MRSA; it has serious side-effects (e.g. antibiotic-associated colitis)

clindamycin

a semisynthetic bacteriostatic antibiotic derivative of lincomycin with improved activity against anaerobic bacteria. It also has some antiprotozoal activity.
References in periodicals archive ?
Ampicillin/sulbactam must be given four times a day when used intramuscularly or intravenously, but intramuscular clindamycin can be administered only twice a day.
Resistance to erythromycin, clindamycin, tetracycline, and virginiamycin [an analog to quinupristin/ dalfopristin, which is used to treat vancomycin-resistant Enterococcus faecium infections in humans (Johnson and Livermore 1999)] was investigated.
Antibiotics of choice include penicillin, erythromycin, and clindamycin.
CDC has obtained a small supply of sulfadiazine/triple sulfa that will be made available to persons with acute disease who cannot tolerate clindamycin and for congenitally infected infants.
In addition, daptomycin "may also represent an alternative to empiric clindamycin in settings of relatively high clindamycin resistance (for either MRSA or MSSA [methicillin-susceptible S.
aureus (MSSA) remained stable, suggesting that declining clindamycin susceptibility is a result of an increase in inducible resistance.
aureus isolates with constitutive resistance show resistance to erythromycin and clindamycin and isolates with inducible resistance are resistant to erythromycin, but appear susceptible to clindamycin.
Side effects in the clindamycin gel and vehicle study arms were virtually identical, with 3% of each group experiencing one or more irritation-type adverse events, such as dryness or redness.
The following antibiotic disks were applied on an inoculated media: azithromycin (Az-15 [micro]g), spiramycin (Sp 100 [micro]g), telithromycin (Te-15 [micro]g), quinupristin-dalfopristin (Q-D-15 [micro]g), and linezolid (Li-30 [micro]g), erythromycin (E-15 [micro]g), and clindamycin (Cl-2 [micro]g) disks were placed by hand to provide distances of 15-26 mm from edge to edge.
Among the 24% of women who did not receive appropriate antibiotic therapy, 80% received clindamycin and 10% received erythromycin, even though antimicrobial resistance has been increasing in the United States, with up to 15% of GBS isolates being resistant to clindamycin and 25% being resistant to erythromycin, she said.
Although high-level resistance to fluoroquinolone antimicrobial agents has been well documented in PCR 027 (1,6), resistance to clindamycin is rare.
If an isolate of staphylococci tests resistant to erythromycin and susceptible to clindamycin (a lincosamide), it could still possess the inducible MLSB- (iMLSB-) resistance mechanism.