click-murmur syndrome

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1. shaped like a miter (tall pointed hat worn by Roman Catholic bishops).
2. pertaining to the left atrioventricular valve.
mitral valve prolapse (MVP) a condition in which some portion of the mitral valve is pushed back into the left atrium during ventricular contraction. For reasons not fully understood (there is no evident disease process) there is redundant tissue on one or both leaflets of the valve. The prolapsed portion of the valve causes a clicking sound halfway through the ventricular contraction, which is followed by a systolic murmur as blood is regurgitated back through the mitral valve into the left atrium. Echocardiography can demonstrate the mitral valve as it prolapses into the left atrium. Called also click-murmur syndrome and Barlow's syndrome.

The condition was first noted in association with potentially serious complications such as infective endocarditis, transient ischemic attack, and arrhythmias. However, in the vast majority of persons in whom mitral valve prolapse is detected by auscultation, the condition is benign and there are no other symptoms.

Mitral valve prolapse is found in persons of all ages and is fairly common, particularly in women. The few who have problems usually experience chest pain, dyspnea, palpitations, fatigue, and sometimes syncope. Electrocardiographic studies may show some premature ventricular contractions, but unlike those in coronary heart disease, these do not indicate injury to the heart muscle.

Persons who suffer from the above symptoms may require administration of a beta-adrenergic blocking agent such as propranolol, restriction of caffeine intake, and avoidance of heavy meals. Those with severe symptoms may require repair or replacement of the mitral valve. It is recommended that patients with mitral valve prolapse take antibiotics prior to dental procedures.


1. the falling down or downward displacement of a part or viscus; called also procidentia and ptosis.
2. to undergo such displacement.
prolapse of cord protrusion of the umbilical cord ahead of the presenting part of the fetus in labor.
Variations of prolapsed umbilical cord. From McKinney et al., 2000.
prolapse of the iris protrusion of the iris through a wound in the cornea.
mitral valve prolapse see mitral valve prolapse.
rectal prolapse (prolapse of rectum) protrusion of the rectal mucous membrane through the anus.
prolapse of uterus downward displacement of the uterus so that the cervix is within the vaginal orifice (first-degree prolapse), the cervix is outside the orifice (second-degree prolapse), or the entire uterus is outside the orifice (third-degree prolapse).
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

click-murmur syndrome

Mitral valve prolapse, see there, aka Barlow's syndrome.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.