cleaved cell

cleaved cell

a cell with single or multiple clefts in the nuclear membrane.
A malignant lymphocyte with one or more deep clefts, linear infoldings of the nucleus, condensed chromatin and indistinct nucleoli. Cleaved cells are typical of follicular small cleaved cell lymphoma, an intermediate grade lymphoma which, despite widespread disease at the time of diagnosis, has a relatively prolonged and non-aggressive course. Large cleaved cells are typical of immunoblastic lymphoma (IL)
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Most common morphologic type noted was clinically aggressive intermediate grade diffuse small cleaved cell type.
Other histological patterns have been described as small cell lymphocytic, diffuse small cleaved cell, large cell immunoblastic and polymorphous types.
4:1 Follicular predominantly small cell -- -- Follicular mixed small and large cell 28-46 1:2 Follicular predominantly large cell 24-46 2:1 Diffuse small cleaved cell 11-67 1:1.
Expression of p53 protein is significantly increased in follicular large cell lymphoma (grade 3) compared with follicular small cleaved cell lymphoma (grade 1) in adults.
Fortunately, the incidence is much less for large cell than for small cleaved cell lymphoma.
small lymphocytic, consistent with CLL (SL) follicular, predominantly small cleaved cell (FSC) follicular, mixed small cleaved and large cell (FM)
cells in 51% of nodular small cleaved cell lymphomas studied.
Diffuse, large noncleaved cell lymphoma is the most common subtype, followed by large cell immunoblastic and large cleaved cell types.
We report the unusual case of a 73-year-old man with follicular small cleaved cell lymphoma involving a right groin lymph node 13 years before present admission who had a composite lymphoma, with a combination of nodular sclerosing Hodgkin disease (HD) and follicular small cleaved cell lymphoma.
The neoplastic cells vary from small to large, showing folding and cleaving of the nuclei, resembling centrocytes (small- to medium-sized cleaved cells with inconspicuous nucleoli) and centroblasts (large noncleaved cells with vesicular chromatin and several peripheral nucleoli).
The follicles were composed of predominantly small cleaved cells.
2] The neoplastic B lymphocytes display a heterogeneous spectrum of morphology, including centroblasts, immunoblasts, multilobated, multinucleated, RS-like cells (especially the lymphocytic and histiocytic [L&H] variants of RS cells), as well as large cleaved cells and large non-cleaved cells.