cleavage site


Also found in: Dictionary, Thesaurus, Financial, Encyclopedia.

re·stric·tion site

a site in nucleic acid in which the bordering bases are of such a type as to leave them vulnerable to the cleaving action of an endonuclease.
Synonym(s): cleavage site

re·stric·tion site

(rĕ-strik'shŭn sīt)
A site in nucleic acid in which the bordering bases are of such a type as to leave them vulnerable to the cleaving action of an endonuclease.
Synonym(s): cleavage site.

cleavage site

The location on a polypeptide molecule where peptide bonds are broken down by hydrolysis.
See also: site
References in periodicals archive ?
Huo et al., "Comprehensive analysis of amino acid sequence diversity at the F protein cleavage site of Newcastle disease virus in fusogenic activity," PLoS ONE, vol.
Sequential steps in HIV particle maturation revealed by alterations of individual Gag polyprotein cleavage sites. J Virol, 1998, 72, 2846-2854.
Virus characterization and sequence of the fusion protein gene cleavage site of recent Newcastle disease virus field isolates from the southeastern United States and Puerto Rico.
The positively charged histidine residues (98, 100, and 102) of [kappa]-casein, which are located prior to the cleavage site, appear to be able to interact with negatively charged residues of chymosin, which are quite distant from the active site.
By incorporating a small section of the fabric filter material into a breaker core, a cleavage site is introduced, allowing for a uniform fracture surface that does not cause a jagged surface that might break into the casting.
Normally, APP's cleavage site remains well protected, buried within the lipid matrix of a cell membrane.
All 2015-2016 Pakistan lineage viruses possessed a low pathogenic motif (KSSR/G) in the HA cleavage site. To further characterize the recent evolution of H9N2 viruses in Pakistan, we mapped the HA and NA amino acid substitutions onto the phylogenetic trees and used Mixed Effects Model of Evolution (MEME) analysis to detect amino acids under positive selection, as previously described (11).
AW-14 isolate was categorized as a velogenicNDV strain assessed biologically by the ICPI (1.8) and polybasic amino acid residues at the F protein cleavage site. The complete genome was 15,192 nucleotides (nt) in length with six genes in order of 3-NP-P-M-F-HN-L-5.
The calculated molecular weight of crucian carp Wap65 protein (CcWap65) is 50.8kDa, containing a signal peptide cleavage site between amino acids 18 and 19.
LOCALIZATION OF THE THROMBIN CLEAVAGE SITE ON cTnT BY WESTERN BLOTTING
Ribonuclease Dicer acts as a molecular ruler: it counts the distance between 3' or 5' end and the cleavage site; next, it performs the cut which releases the miRNA:miRNA* duplex [25-27].