cleavage

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cleavage

 [klēv´ij]
1. division into distinct parts.
2. the early successive splitting of a fertilized ovum (zygote) into smaller cells (blastomeres) by mitosis.

cleav·age

(klēv'ij),
1.
See also: cleavage division.
See also: Langer lines, tension lines. Synonym(s): intermammary cleft
2. Series of mitotic cell divisions occurring in the oocyte immediately following its fertilization.
See also: cleavage division.
See also: Langer lines, tension lines. Synonym(s): segmentation (2)
3. Splitting of a complex molecule into two or more simpler molecules.
See also: Langer lines, tension lines. Synonym(s): scission (2)
4. Linear clefts in the skin indicating extrinsic stresses being applied in that area.
See also: Langer lines, tension lines.
5. The tendency of a crystal to break along a preferred direction or plane.

cleavage

(klē′vĭj)
n.
1. Embryology
a. The series of mitotic cell divisions that produces a blastula from a fertilized ovum. It is the basis of the multicellularity of complex organisms. Also called segmentation.
b. Any single cell division in such a series.
2. Chemistry The splitting of a complex molecule, such as a polysaccharide, into simpler molecules.

cleavage

Embryology
The mitotic divisions of a zygote (fertilised egg) to form a blastomere (cleavage cells).
 
Vox populi
The act of splitting or cleaving.

cleav·age

(klēv'ăj)
1. Series of mitotic cell divisions occurring in the oocyte immediately after its fertilization.
See also: cleavage division
2. Splitting of a complex molecule into two or more simpler molecules.
Synonym(s): scission (2) .
3. Linear clefts in the skin indicating the direction of the fibers in the dermis.
See also: cleavage lines

cleavage

1. The process of splitting, especially the repeated stages of cell division that produce a BLASTULA from an ovum that has been fertilized by a spermatozoon.
2. The breaking down of a complex molecule into smaller parts.
3. The vertical furrow between a woman's breasts visible when low-cut garments are worn.
Cleavageclick for a larger image
Fig. 109 Cleavage . Radial and spiral cleavage.

cleavage

the division of the cytoplasm during nuclear division (see MEIOSIS, MITOSIS following FERTILIZATION of the egg to form the ZYGOTE. Holoblastic cleavage occurs in animals where there is little yolk, and here the entire zygote is involved; meroblastic cleavage occurs where the yolky part of the zygote fails to divide, only part of the zygote undergoing cleavage. BILATERAL CLEAVAGE gives rise to a bilaterally symmetrical arrangement of blastomeres, as opposed to spiral cleavage which gives rise to a spiral arrangement of blastomeres. Bilateral cleavage occurs in chordates, echinoderms and a few smaller groups, indicating their common origins whereas most other invertebrate phyla have spiral cleavage.
References in periodicals archive ?
When faced with the question of whether the written description would have enabled a PHOSITA at the time of filing to use cleavable fusion expression to make HGH without undue experimentation, (135) the Federal Circuit determined that it did not:
Durham, today most systems use cleavable 2-alkyl-2-adamantane methacrylate copolymerized with lactone and fused ring alcohols in order to offset the high hydrophobicity of the adamantane ring.
These patients tend to have limited skin disease, are anticentromere positive, and demonstrate granzyme B cleavable autoantigens.
This new class of materials, "could prove useful in diverse fields as textile processing, electronics fabrication, sample management, wastewater processing, and cleavable phase transfer reagents," says Scott Vaupen, business development associate at Sandia.
Marker LW8, a cleavable amplified polymorphic sequence (CAPS) marker located 3.18 cM from the rf4 locus, is 275 bp in IS1112C and 310 bp in B3Tx398.
Applied Biosystems launched its Cleavable ICAT Reagent Technology ...
Tisotumab vedotin is an antibody-drug conjugate (ADC) composed of Genmab's human antibody that binds to Tissue Factor (TF) and Seattle Genetics' ADC technology that utilizes a cleavable linker and the cytotoxic drug monomethyl auristatin E (MMAE).
Wang et al., "A tumor-specific cleavable nanosystem of PEG-modified C60@Au hybrid aggregates for radio frequency-controlled release, hyperthermia, photodynamic therapy and X-ray imaging," Acta Biomaterialia, vol.
They also showed that the potency of these drugs to stimulate topo II cleavable complexes correlated with their ability to undergo Michael addition (Wang et al., 2001).
A water soluble SWCNT-Paclitaxel (PTX) conjugate has been developed by conjugating PTX to functionalized polyethylene glycol SWCNTs via a cleavable ester bond.
Genistein was shown to act as a topoisomerase II inhibitor and to cause DNA damage manifested by micronuclei and histone H2A.X staining, in a consequence of a formation of cleavable complexes [16].