clear cell adenocarcinoma

Also found in: Dictionary, Thesaurus, Encyclopedia.


carcinoma derived from glandular tissue or in which the tumor cells form recognizable glandular structures. The World Health Organization recognizes four categories of adenocarcinoma: acinar, papillary, bronchioalveolar, and solid carcinoma with mucus formation; it can be further subclassified into well, moderate, and poorly differentiated forms.
alveolar adenocarcinoma (bronchioalveolar adenocarcinoma) (bronchiolar adenocarcinoma) (bronchioloalveolar adenocarcinoma) (bronchoalveolar adenocarcinoma) bronchioloalveolar carcinoma.
clear cell adenocarcinoma a rare malignant tumor of the female genital tract, resembling a renal cell carcinoma and containing tubules or small cysts with some cells that are hobnail-shaped and others whose cytoplasm is clear, containing abundant glycogen and inconspicuous stroma. It may occur in the ovary, uterus, cervix, or vagina. One form has been linked to in utero exposure to diethylstilbestrol. Called also clear cell carcinoma and mesonephroma.
adenocarcinoma of the lung a type of bronchogenic carcinoma made up of cuboidal or columnar cells in a discrete mass, usually at the periphery of the lungs.

clear cell ad·e·no·car·ci·no·ma

1. a histologic type of renal adenocarcinoma;
2. a histologic type of adenocarcinoma occurring chiefly in the male and female genitourinary tracts that is characterized by distinctive hobnail-cell growth of neoplastic cells in sheets, papillae, and coalescing glands.
A malignancy of the vagina and uterine cervix; 2/3 of such malignancies occur in young women exposed in utero to estrogen analogues, especially DES, as well as hexestrol or dienestrol
Risk The relative risk for DES exposed individuals is 0.014
Prognosis 5-yr survival, 80+% with local recurrence
References in periodicals archive ?
Pan, "CA125-producing Clear Cell Adenocarcinoma Arising From the Upper Ureter and Renal Pelvis," Journal of the Chinese Medical Association, vol.
The most common histological type of endometriosis-associated carcinoma in the groin is clear cell adenocarcinoma [15].
(i) Clear cell adenocarcinoma (CCA): CCA usually occurs in women; it lacks clinical characteristics of adenoma; CCAs tend to be very large tumours; microscopically CCAs exhibit mostly clear cells; there is marked atypia in CCAs; there is muscularis propria invasion in CCA; there is additionally high mitotic rate in CCA; there is necrosis in CCA; there is high Ki-67 percentage in CCA; in CCA, usually PAX2 is negative (even though distinction is usually made upon morphologic grounds); CCA exhibits strong staining with p63 [22-24].
Vaginal clear cell adenocarcinoma with associated Mullerian duct anomalies, renal agenesis and situs inversus: report of a case with no known in-utero exposure with diethyl stilboestrol.
Chaudhary, "A rare case of clear cell adenocarcinoma of the bladder with unique pathological features," The American Journal of the Medical Sciences, vol.
Cystoscopy was significant for a sizeable papillary urethral mass emanating from a urethral diverticulum, the biopsy of which yielded a diagnosis of clear cell adenocarcinoma. A contrast enhanced MRI of the pelvis revealed a 5.1 cm x 4.3 cm x 4.0 cm urethral diverticulum containing a 4.4 cm x 3.2 cm x 3.6 cm nodular enhancing mass concerning malignancy (Figures 1(a) and 1(b)).
Clear Cell Adenocarcinoma with Enteroblastic Differentiation of the Ascending Colon.
Clear Cell Adenocarcinoma Versus Carcinomas Containing Clear Cells.--Squamous cell carcinomas may have clear cells due to abundant intracytoplasmic glycogen; however, typical areas of squamous cell carcinoma are often present and characteristic patterns of clear cell carcinoma are lacking.
Nonintestinal adenocarcinoma can be clear cell adenocarcinoma or adenocarcinoma of nonspecific type.
Clear cell adenocarcinoma is an unusual and rare variant of bladder adenocarcinoma with a particularly strong predilection for females, with a reported mean age of 57 years.
Nephrogenic adenomas involving the deep lamina propria and/or superficial muscle can cause diagnostic difficulty and mimic malignancy, specifically prostatic adenocarcinoma, urothelial carcinoma with bland histology, and/or clear cell adenocarcinoma (Table).
Many of the special subtypes, such as clear cell adenocarcinoma, are rarely encountered.