clear cell adenocarcinoma

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carcinoma derived from glandular tissue or in which the tumor cells form recognizable glandular structures. The World Health Organization recognizes four categories of adenocarcinoma: acinar, papillary, bronchioalveolar, and solid carcinoma with mucus formation; it can be further subclassified into well, moderate, and poorly differentiated forms.
alveolar adenocarcinoma (bronchioalveolar adenocarcinoma) (bronchiolar adenocarcinoma) (bronchioloalveolar adenocarcinoma) (bronchoalveolar adenocarcinoma) bronchioloalveolar carcinoma.
clear cell adenocarcinoma a rare malignant tumor of the female genital tract, resembling a renal cell carcinoma and containing tubules or small cysts with some cells that are hobnail-shaped and others whose cytoplasm is clear, containing abundant glycogen and inconspicuous stroma. It may occur in the ovary, uterus, cervix, or vagina. One form has been linked to in utero exposure to diethylstilbestrol. Called also clear cell carcinoma and mesonephroma.
adenocarcinoma of the lung a type of bronchogenic carcinoma made up of cuboidal or columnar cells in a discrete mass, usually at the periphery of the lungs.

clear cell ad·e·no·car·ci·no·ma

1. a histologic type of renal adenocarcinoma;
2. a histologic type of adenocarcinoma occurring chiefly in the male and female genitourinary tracts that is characterized by distinctive hobnail-cell growth of neoplastic cells in sheets, papillae, and coalescing glands.
A malignancy of the vagina and uterine cervix; 2/3 of such malignancies occur in young women exposed in utero to estrogen analogues, especially DES, as well as hexestrol or dienestrol
Risk The relative risk for DES exposed individuals is 0.014
Prognosis 5-yr survival, 80+% with local recurrence
References in periodicals archive ?
Clear cell adenocarcinoma of the uterine cervix arising from a background of cervical endometriosis.
ii) the results of molecular studies, particularly comparative genomic hybridization analysis, suggested clonal evolution of nephrogenic metaplasia to clear cell adenocarcinoma in their case.
Morphologic similarities between the clear cell carcinomas arising at diverse sites and the uncommon occurrence of clear cell adenocarcinoma within the colon make it difficult to differentiate this variant of colonic adenocarcinoma from a metastatic process.
Primary clear cell adenocarcinomas (PCCA) most commonly involve the vagina, cervix, ovaries, and urinary tract including the kidneys.
Type of tumor Number Percentage 1 Serous Cystadenoma 19 38% 2 Serous Cystadenofibroma 4 8% 3 Borderline Serous Tumor 2 4% 4 Serous Cystadenocarcinoma 4 8% 5 Mucinous Cystadenoma 10 20% 6 Borderline Mucinous Tumor 3 6% 7 Mucinous Cystadenocarcinoma 4 8% 8 Endometrioid Carcinoma 2 4% 9 Clear Cell Adenocarcinoma 1 2% 10 Brenner Tumor 1 2% Total 50 100%
Adeniran and Tamboli [10] in their review of clear cell carcinoma of the urinary bladder stated (see Figures 7(a), 7(b), 7(c), 7(d), 7(e), and 7(f) for various microscopic and immunohistochemical staining pictures of clear cell adenocarcinoma of bladder and some differential diagnoses) the following.
Clear Cell Adenocarcinoma Versus Carcinomas Containing Clear Cells.
25) Other lesions that need to be distinguished from clear cell adenocarcinoma include vaginal or cervical clear cell carcinomas, clear cell prostatic adenocarcinoma, and metastatic clear cell renal cell carcinoma.
Another rare entity that may mimic NA is clear cell adenocarcinoma (Figure 2, G and H); this tumor may show foci with tubular, cystic, and papillary architecture lacking significant cytologic atypia, focally resembling NA.
Many of the special subtypes, such as clear cell adenocarcinoma, are rarely encountered.
Clear cell adenocarcinoma of the urethra: a clinicopathologic analysis of 19 cases.
Clear cell adenocarcinoma (CCA) usually arises from the female genital tract.