clavulanic acid


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clav·u·lan·ic ac·id

(klav'yū-lan'ik as'id),
A β-lactam structurally related to the penicillins that inactivate β-lactamase enzymes in penicillin-resistant organisms; usually used in combination with penicillins to enhance and broaden the spectrum of the penicillins.

clavulanic acid

(klăv′yo͝o-lăn′ĭk)
n.
A compound, C8H9NO5, originally obtained from the bacterium Streptomyces clavuligerus, that inhibits action of the enzyme beta-lactamase, thus counteracting bacterial resistance to beta-lactam antibiotics. It is used in combination with antibiotics such as amoxicillin to treat infections caused by antibiotic-resistant bacteria.

clavulanic acid

A drug that interferes with beta-lactamase enzymes that inactivate many penicillin-type antibiotics, such as AMOXICILLIN. Combined with the antibiotic, this drug can overcome drug resistance.

clav·u·lan·ic ac·id

(klav'yū-lan'ik as'id)
A β-lactam structurally related to the penicillins that inactivates β-lactamase enzymes in penicillin-resistant organisms.
References in periodicals archive ?
Conventional E-strips differ from these in that they contain a gradient of 3 antibiotics on either side with or without clavulanic acid respectively instead of one antibiotic.
After the incubation of 24 hr the culture plate was studied for zone of inhibition in an area between ceftriaxone and amoxicillin clavulanic acid in comparison with the zone of inhibition on the far side of these drugs was taken as a positive.
Avibactam has much broader coverage than clavulanic acid against beta lactamase enzymes that bacteria make to defend themselves against antibiotics such as penicillins, cephalosporins and carbapenems.
The ESBL E-strip is a plastic drug-impregnated strip, strips were impregnated with cefotaxime (CTX) at one end and cefotaxime + clavulanic acid (CTX+) at another end.
The results of the study have shown that that severe cases of pyoderma in goats could be effectively treated with the combination of amoxicillin and clavulanic acid.
They impart resistance to penicillins, cephalosporins and monobactams except 4th generation cephalosporins and are not inhibited by [beta]-lactamase inhibitor.7 They can be differentiated from ESBLs in their hydrolysis of cephamycins along with other cephalosporins except fourth generation and no inhibition by clavulanic acid.8
The results of antibiotic sensitivity testing (Table 3) indicated Ceftiofur sodium (100%) as the most efficacious antibiotic for respiratory affections caused by Staphylococcus aureus in calves followed by Amoxicillin/ Clavulanic acid, Enrofloxacin and Cephalexin.
All had an abdominal CT scan and received intravenous antibiotics, either an initial infusion of 1 g of amoxicillin per 125 mg of clavulanic acid, or, in the case of those with a penicillin allergy, ciprofloxacin 200 mg and metronidazole 500 mg (Ann.
coli isolates, 82 were phenotypically detected as ESBL producers by standard cefotaxime / clavulanic acid and ceftazidime / clavulanic acid disc diffusion tests.
Similarly, the content of Clavulanic Acid in the freshly prepared sample was 20 per cent less than the IP 2007 limit.
(1,2) The ESBL are plasmid-mediated enzymes with the capability to hydrolyze and inactivate broad spectrum of [beta]-Lactam antimicrobials, including third-generation cephalosporins, penicillins and aztreonam; but are inhibited by clavulanic acid. (2-4) The two most common plasmid mediated [beta]-Lactamases are the TEM-1 and SHV-1 family mainly expressed in Escherichia coli and Klebsiella pneumoniae, respectively; that confer resistance to antimicrobials.