CLDN8

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CLDN8

A gene on chromosome 21q22.11 that encodes claudin-8, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction. Claudin-8 plays important roles in the cation barrier of the distal renal tubule, and in preventing sodium back-leakage in the distal colon.

Molecular pathology
Differential expression of claudin-8 occurs in colorectal carcinoma and renal cell tumours, and, with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
References in periodicals archive ?
CD is also associated with both the redistribution and decreased expression of claudin-3, claudin-5, and claudin-8, as well as increased expression of claudin-2 [27, 33].
However, in Western blots, no significant differences were detected in the expression of the TJ proteins claudin-1, claudin-3, claudin-4, claudin-5, claudin-7, or claudin-8 between bacterial treatments (Figure 3).
Our previous study had demonstrated the presence of claudin-1, claudin-3, claudin-4, claudin-5, claudin-7, and claudin-8 in IPEC-J2 cells [24].
The present study has focused on claudin-1, claudin-3, claudin-4, and claudin-5, which are barrier-forming proteins, claudin-8 conveying a barrier for cations, and claudin-7, which is involved in changes in [Cl.sup.-] and [Na.sup.+] conductance [16, 32-34].
Krug et al., "Na+ absorption defends from paracellular back-leakage by claudin-8 upregulation," Biochemical and Biophysical Research Communications, vol.
Hou, "KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8," Proceedings of the National Academy of Sciences of the United States of America, vol.
Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.