CLDN7

(redirected from claudin-7)

CLDN7

A gene on chromosome 17p13.1 that encodes claudin-7, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
Differential expression of CLDN7 has been described in malignancies of the breast, ovary, liver, urinary tract, prostate, lung, head, neck, thyroid and elsewhere.
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References in periodicals archive ?
Schmidt et al., "The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7," Experimental Cell Research, vol.
However, in Western blots, no significant differences were detected in the expression of the TJ proteins claudin-1, claudin-3, claudin-4, claudin-5, claudin-7, or claudin-8 between bacterial treatments (Figure 3).
Our previous study had demonstrated the presence of claudin-1, claudin-3, claudin-4, claudin-5, claudin-7, and claudin-8 in IPEC-J2 cells [24].
The present study has focused on claudin-1, claudin-3, claudin-4, and claudin-5, which are barrier-forming proteins, claudin-8 conveying a barrier for cations, and claudin-7, which is involved in changes in [Cl.sup.-] and [Na.sup.+] conductance [16, 32-34].
Chen, "Overexpression of claudin-7 decreases the paracellular Cl--conductance and increases the paracellular Na+ conductance in LLCPK1 cells," Journal of Cell Science, vol.
Claudin-7 and claudin-8: immunohistochemical markers for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
Yu, "Expression of claudin-7 and -8 along the mouse nephron," American Journal of Physiology--Renal Physiology, vol.
However, active UC is associated with the redistribution and decreased expression of claudin-1, claudin-4, claudin-7, and occludin, as well as a notable increase in claudin-2 expression [27, 33].
Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma.
Claudin-7 immunohistochemistry in renal tumors: a candidate marker for chromophobe renal cell carcinoma identified by gene expression profiling.