CLDN5

(redirected from claudin-5)

CLDN5

A gene on chromosome 22q11.21 that encodes claudin-5, an integral membrane protein of the claudin family, the members of which form a physical physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
CLDN5 mutations are linked to velocardiofacial syndrome.
References in periodicals archive ?
Intestinal histology, lactulose, mannitol concentrations were measured, and zonula occludens (ZO)-1, occludin and claudin-5 transcription (polymerase chain reaction), translation (by Western blot analysis), and expression (by immunohistochemistry) were also measured.
However, a stronger correlation was observed with serum CA125 and claudin-5 expression, supporting previous findings (15).
In the same way, sleep restriction decreased the mRNA levels of the tight junction proteins claudin-5, zonula occludens-2 (ZO-2), and occludin [8].
Under pathological conditions, ROS significantly contribute to blood-brain barrier dysfunction and inflammation in the brain by enhancing cellular migration, paralleling with cytoskeleton rearrangements and redistribution of disappearance of tight junctions proteins claudin-5 and occludin [71].
The blood brain barrier is formed by claudins, and claudin-5 knockout in mice changes the permeability of the blood brain barrier even to a primary amine-reactive biotinylation reagent.
Endothelial cells of the hemangioma component were positive for claudin-5 endothelium-specific immunohistochemical marker, and the leiomyoma component was positive for a-smooth muscle actin.
We investigated the effects of GTPs on the expression of claudin-5, occludin, and ZO-1, and the corresponding cellular mechanisms involved in the early stage of cerebral ischemia.
RESULTS: Oral administration of coplanar PCB126, mono-ortho-substituted PCB118, and non-coplanar PCB153 (each at 150 [micro]mol/kg body weight) differentially altered expression of the TJ proteins claudin-5, occludin, and zonula occludens-1 in brain capillaries.
The team are already working on a way to block claudin-5 production in the eye only.
Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability.
Overexpression of claudin-5 but not claudin-3 induces formation of trans-interaction-dependent multilamellar bodies
Liu, "Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage," Journal of Neuroscience, vol.