CLDN5

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CLDN5

A gene on chromosome 22q11.21 that encodes claudin-5, an integral membrane protein of the claudin family, the members of which form a physical physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
CLDN5 mutations are linked to velocardiofacial syndrome.
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References in periodicals archive ?
The scientists discovered that a key component of the cells lining the retinal blood vessels, namely claudin-5, may be central to the development of the common blinding eye disease, AMD.
(2011a) showed that pericytes influenced the expression of claudin-5, an important component of the BNB, by endothelial cells through secretion of growth factors.
Hyperstimulation and a gonadotropin-releasing hormone agonist modulate ovarian vascular permeability by altering expression of the tight junction protein claudin-5. Endocrinology 2006 Feb;147(2):694-699.
Serum levels of endocan, claudin-5 and cytokines in migraine.
The vehicle- and scrambled RNA-treated SAH mice also expressed significantly less ZO-1, occludin, and claudin-5 than did the sham mice.
PB-MNC, stimulated or not with ephrin-B2, did not modify Evans blue extravasation (N = 6 - 7) or occludin, claudin-5, ZO-1, or VE-cadherin mRNA expression compared to PBS (N =5 - 7) (Figure 5).
qPCR primer sets for VEGF, fibroblast growth factor-2 (FGF-2), claudin-1 and claudin-5, ZO-1, GFAP, caspase-3, uPAR, FPRs, tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin--(IL-) 1[beta], and IL-6 were chosen to hybridize to unique regions of the appropriate gene sequence (see Table 1 for a complete list of assayed genes and primers).
GFAP and claudin-5 can be found both in the BBB and the enteric nervous system, which permeates the GI tract [42-44].
Corticosteroids are known for their anti-inflammatory and antiangiogenic activity; they counteract macrophages and related cytokines involved in inflammation and neovascularization [20], modulate signaling pathway and effector proteins downstream of the VEGF receptor [21], restore the blood retinal barrier (BRB) through the induction of tight-junction proteins (occludin and claudin-5) [22], and modulate active microglia [23].
Cx40 and Cx43 are associated with TJ proteins (occludin and claudin-5) in porcine brain ECs through cytoplasmic scaffold proteins, such as ZO-1.
CD is also associated with both the redistribution and decreased expression of claudin-3, claudin-5, and claudin-8, as well as increased expression of claudin-2 [27, 33].
Intestinal histology, lactulose, mannitol concentrations were measured, and zonula occludens (ZO)-1, occludin and claudin-5 transcription (polymerase chain reaction), translation (by Western blot analysis), and expression (by immunohistochemistry) were also measured.