CLDN4

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CLDN4

A gene on chromosome 7q11.23 that encodes claudin-4, an integral membrane protein of the claudin family, the members of which form part of the tight junction strands and may play a role in embryonic and post-natal organogenesis and function.

Molecular pathology
CLDN4 is deleted in Williams-Beuren syndrome, a multisystem neurodevelopmental disorder.
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Furthermore, their permeability increased after stretch as TJs protein (occludin, claudin-4) dissociated from zona occludins-1.
Value of PAX8, PAX2, claudin-4, and h-caldesmon immunostaining in distinguishing peritoneal epithelioid mesotheliomas from serous carcinomas.
Epidermal KC-specific ZEB-2 overexpression in mice showed epidermal barrier impairment along with the loss of expression of occludin and claudin-4 [63].
Immunohistochemical staining for TJs (JAM-1, 1:100, Abcam; claudin-4, 1:200, Abcam; occludin, 1:100, Proteintech) was performed as described previously [19].
Kim, "Low expression of claudin-4 is associated with poor prognosis in esophageal squamous cell carcinoma," Annals of Surgical Oncology, vol.
Frommet al., "Transforming growth factor-[beta], a whey protein component, strengthens the intestinal barrier by upregulating claudin-4 in HT-29/B6 cells," Journal of Nutrition, vol.
This effect was ascribed to the increased expression of tight junction components of ZO-1 and claudin-4 transcription and reduced occludin expression.
Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability.
However, active UC is associated with the redistribution and decreased expression of claudin-1, claudin-4, claudin-7, and occludin, as well as a notable increase in claudin-2 expression [27, 33].
However, in Western blots, no significant differences were detected in the expression of the TJ proteins claudin-1, claudin-3, claudin-4, claudin-5, claudin-7, or claudin-8 between bacterial treatments (Figure 3).
demonstrated that the addition of IL-4 or IL-13 increases the permeability of airway epithelial cell monolayers in vitro, which is accompanied by the appearance of intercellular gaps and the accumulation of claudin-4 in cytoplasmic vesicles [131].