CLDN18

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CLDN18

A gene on chromosome 3q22.3 that encodes claudin-18, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction. CLDN18 expression in gastric cells is regulated by the PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1)-dependent pathway.

Molecular pathology
CLDN18 is upregulated in ulcerative colitis and seriously overexpressed in infiltrating ductal adenocarcinomas.
References in periodicals archive ?
Finally, while not extensively studied in the context of the proposed diagnostic classification by Amin et al, (14) claudin-18 appears to be expressed in a significant proportion of noncystic urachal adenocarcinomas but not mucinous cystic tumors (15); however, additional data are needed to support the potential utility of claudin-18 in this specific differential diagnosis.
Further potential markers include Claudin-18 and Reg IV, however, with no available data in primary bladder adenocarcinomas.
Okugawa et al., "Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front," PLoS One, vol.
Predesigned primers for Claudin-3 (Mm00515499_s1) and Claudin-18 (Mm00517321_m1) were purchased from Life Technologies.
Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.
The gastrointestinal tract markers claudin-18 and Reg IV can also be expressed by the urachal adenocarcinomas [1].
Expression of olfactomedin 4 and claudin-18 in serrated neoplasia of the colorectum: a characteristic pattern is associated with sessile serrated lesion.