CLDN15

(redirected from claudin-15)

CLDN15

A gene on chromosome 7q11.22 that encodes claudin-15, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction. Claudin-15 is thought to play a key role in tight junction-specific obliteration of the intercellular space by means of a calcium-independent mechanism.
References in periodicals archive ?
Mice with claudin-2 or claudin-15 deficiencies in the small intestine reveal that these transmembrane proteins play essential roles in the transepithelial paracellular channel-like permselectivity for extracellular monovalent cations, especially Na(+), in both infants and adults [13].
Imasato et al., "Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine," Gastroenterology, vol.
We analyzed the structure of claudin-15 by X-ray crystallography and revealed that the transmembrane segments form a tight left-handed fourhelix bundle and two extracellular loops form a characteristic [beta]-structure (42) (Fig.
The paracellular channel formed by claudin-15 with acidic residues in the extracellular domain, as shown on the negative surface of the palm model (Fig.
A recent study found up-regulation of Atlantic salmon claudin-15 and -25b mRNA upon SW acclimation, which supported a modification of the paracellular barrier in SW-acclimated fish intestine (Tipsmark et al., 2010a).