CLDN1

(redirected from claudin-1)

CLDN1

A gene on chromosome 3q28-q29 that encodes claudin-1, an integral membrane protein of the claudin family, the members of which form part of tight junction strands, providing a continuous seal around cells and serving as a physical barrier to prevent solutes and water from passing freely into the interstitial space.

Molecular pathology
CLDN1 loss of function mutations cause neonatal ichthyosis-sclerosing cholangitis syndrome.
References in periodicals archive ?
TFF3-peptide increases transepithelial resistance in epithelial cells by modulating claudin-1 and -2 expression.
Claudin-1 and E-cadherin are important component proteins of tight junctions and adhesion junctions, respectively, which control the intestinal epithelium paracellular pathway (Tang & Goodenough, 2003; Lee et al.
Like normal perineurial cells, tumor cells in perineuriomas usually express EMA and claudin-1, the commonly used perineurial markers.
1% Tween-20) for 2 h at room temperature, sequential incubated with primary antibody for occludin, claudin-1 and ZO-1 (1:500, diluted with TEST) overnight at 4[degrees]C with gentle shaking.
sup][21],[22],[23] Although TXL has been reported to have positive effects on the hypoxia-inhibited claudin-1,[sup][24],[25] whether TXL regulates claudin-5, claudin-9, and claudin-11, which are expressed in the endothelial cells, has not been explored.
The supernatant proteins (30 [micro]g) were separated by 10% SDS-polyacrylamide gel electrophoresis, transferred to polyvinylidenedifluoride membranes, and then hybridized overnight, at 4[degrees]C with 1:1000 diluted antibody of COX-2, iNOS, p65, p-p65, TAK1, p-TAK1, p38, p-p38, JNK, p-JNK, ERK, p-ERK, occludin, claudin-1, ZO-1 or [beta]-actin, then incubated with 1:2000 diluted anti-rabbit or anti-mouse IgG secondary antibody for 1 h at room temperature, and washed 3 times with PBS containing 0.
Several cell receptors were identified as being potential HCV cell entry to the cell, mainly transmembrane lectins as dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) and its liver and lymphatic endothelium homologue (L-SIGN), scavenger member 1 receptor-class B (SR-BI), tight junction proteins such as claudin-1 (CLDN-1) and occludin (OCLN), cluster of differentiation 81 (CD81) protein, and, recently, the very-low-density lipoprotein receptor (VLDLR) [5,6].
Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1.
By several mechanisms, such as coiling in position 1, interaction with X HBV protein, plasmin, furin, focal adhesion molecule (FAK), claudin-1, or other active MMPs results in their activation, thus promoting the process of liver fibrosis and HCC progression [152-155].
1998) Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin.
Tight junctions in thyroid carcinogenesis: diverse expression of claudin-1, claudin-4, claudin-7 and occludin in thyroid neoplasms.