CLDN8

(redirected from claudin 8)

CLDN8

A gene on chromosome 21q22.11 that encodes claudin-8, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction. Claudin-8 plays important roles in the cation barrier of the distal renal tubule, and in preventing sodium back-leakage in the distal colon.

Molecular pathology
Differential expression of claudin-8 occurs in colorectal carcinoma and renal cell tumours, and, with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.
References in periodicals archive ?
If this first IHC panel is inconclusive, additional markers, such as CD82, claudin 7, and claudin 8, can be used.
Immunohistochemical stain for cytokeratin 7, S100A1 and claudin 8 is valuable in differential diagnosis of chromophobe renal cell carcinoma from renal oncocytoma.
Differential Diagnosis of Low-Grade Renal Cell Tumor With Clear Cell/Granular Cell Features3 Antibodies ChRCC Oncocytoma CRCC CK7 Diffusely + -/focally + - Ber-EP4 Diffusely + -/focally + ND S100A1 - + +/- CD15 - +/- - CD82 + - -/+ Claudin 7 + - ND Claudin 8 M+ C+ ND CD117 + + - RCCma - - + CAIX - - + KIM-1 - - + Vim - - + Abbreviations: C, cytoplasmic; ChRCC, chromophobe renal cell carcinoma; CRCC, clear cell renal cell carcinoma; M, membranous.