CLDN7

(redirected from claudin 7)

CLDN7

A gene on chromosome 17p13.1 that encodes claudin-7, an integral membrane protein of the claudin family, the members of which form a physical barrier that prevents solutes and water from passing freely into the interstitial space between epithelial or endothelial cell sheets, and play critical roles in maintaining cell polarity and signal transduction.

Molecular pathology
Differential expression of CLDN7 has been described in malignancies of the breast, ovary, liver, urinary tract, prostate, lung, head, neck, thyroid and elsewhere.
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References in periodicals archive ?
EntrezID Gene full name Gene CombinedRP symbol 1293 Collagen type VI alpha 3 chain COL6A3 59.02 1278 Collagen type I alpha 2 chain COL1A2 62.06 10562 Olfactomedin 4 OLFM4 150.67 7058 Thrombospondin 2 THBS2 163.66 115908 Diffuse panbronchiolitis CTHRC1 174.61 critical region 1 4680 Collagen triple helix repeat CEACAM6 203.78 containing 1 3624 Inhibin beta A subunit INHBA 219.12 1290 Collagen type V alpha 2 chain COL5A2 230.72 54829 Asporin ASPN 255.15 1366 Claudin 7 CLDN7 288.09 EntrezID AveLogFC 1293 3600.96 1278 3576.21 10562 3542.76 7058 24.03 115908 1204.56 4680 2542.02 3624 368.69 1290 1064.68 54829 237.05 1366 356.71
If this first IHC panel is inconclusive, additional markers, such as CD82, claudin 7, and claudin 8, can be used.
This group of markers (parvalbumin, claudin 7 and 8, and CD117) has been shown to be positive in a high percentage of chromophobe RCCs and oncocytomas but is typically negative in other types of RCC.
Limited studies on their expression in renal neoplasm showed that most chromophobe RCC and oncocytoma expressed both claudin 7 and 8, but they are seen in no or very few other RCCs.