CLDN3

(redirected from claudin 3)

CLDN3

A gene on chromosome 7q11.23 that encodes claudin-3, an integral membrane protein of the claudin family, the members of which form part of the tight junction strands providing a continuous seal around cells and serving as a physical barrier to prevent solutes and water from passing freely into the interstitial space.
 
Molecular pathology
Claudin-3 has a low-affinity receptor for Clostridium perfringens enterotoxin.
References in periodicals archive ?
Of interest, we found that arsenic exposure via drinking water induced a dose-dependent increase in claudin 18 mRNA in lung homogenates, whereas claudin 3 expression was unaltered (Figure 7b).
b) Claudin 18 and claudin 3 mRNA (normalized to GAPDH) was quantified in lung homogenates of mice following 5 wk of exposure to drinking water with the indicated arsenic content.