CLDN1

(redirected from claudin 1)

CLDN1

A gene on chromosome 3q28-q29 that encodes claudin-1, an integral membrane protein of the claudin family, the members of which form part of tight junction strands, providing a continuous seal around cells and serving as a physical barrier to prevent solutes and water from passing freely into the interstitial space.

Molecular pathology
CLDN1 loss of function mutations cause neonatal ichthyosis-sclerosing cholangitis syndrome.
References in periodicals archive ?
3C), and claudin 1. It is important to note that the tumour stained negative for myogenin, myoD1, des-min, S-100, nuclear beta-catenin, and MUC4.
Cells grown on the biopaper had significantly higher expression of PDGFB (p = 0.007) and claudin 1 (CLDN1, p = 0.047) but significantly lower expression of VCAM1 (p = 0.017) at this time point.
Mee et al., "CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry," Journal of Virology, vol.
Hanuma Kumar GP Limited, Hyderabad, Claudin 1 is Institute of Pathology prognostic marker (ICMR), Safdarjung for glioblastoma hospital Campus, New Delhi.
However, further investigation led to the identification of claudin 1 & 2, integral membrane proteins that can form strand structures without occludin.