claudin


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claudin

(klaw'din),
A membrane protein, juxtaposed strands of which form tight junctions between epithelial cells.
See also: tight junction, zonula occludens.
[L. claudo, to close up, + -in]

claudin

Any of more than 20 small (less than 22 kD) transmembrane proteins which are part of the proteins in the tight junctions in endothelial and epithelial cells, and are critical for forming the paracellular space through which molecules flow between epithelial cells.
References in periodicals archive ?
Some of the upregulated genes comprised genes with important functions in the immune response and proliferation, such as claudin 4 (CLDN4), orosomucoid 1 (ORM1), insulin-like growth factor binding protein 2 (IGFBP2), cytochrome P450, family 26, subfamily A, polypeptide 1 (CYP26A1), and growth arrest-specific 1 (GAS1).
The most important TJ proteins in the intestinal mucosa are ZO-1, occludin, and claudins [7], and the expression of all 3 in the intestine are decreased by infection with ETEC K88 [24, 30].
Tight junctions have several membrane and cytoplasmic proteins [33] ; some of these such as occludins, claudins, and zona occludins (ZO proteins) have been well studied [34-38].
Claudins are tetraspan membrane proteins essential components of the paracelular barriers found in tight junctions of all epithelia and endothelia which contain a longer intracellular C-terminus through which the majority of human claudins interact with PDZ domains of various proteins (Gunzel & Yu, 2013).
Among the enxtensive literature, for example, Fernando Claudin, La crisis del movimiento comunista.
Claudin, "Stress distribution in granular media and nonlinear wave equation," Journal de Physique I, vol.
(28) Asi lo entiende Lluis Llach, quien considera el monolinguismo como "una de nuestras unicas armas de enfrentamiento contra un sistema centralista y opresor", Claudin, Victor: op.
Scheiner-Bobis, "Non-classical testosterone signaling mediated through ZIP9 stimulates claudin expression and tight junction formation in Sertoli cells," Cellular Signalling, vol.
Little to no expression was observed at any time point in either the biopaper or PET coculture systems for genes gap junction [beta]4 (GJB4), gap junction [beta]6 (GJB6), tight junction protein 3 (TJP3), and claudin 3 (CLDN3) (Table 2).