The coated pits contain the electron dense clathrin
protein and other proteins .
The team determined that this protein is a specialized form of an omnipresent housekeeping protein called clathrin
, which is known to be instrumental in moving proteins between cellular compartments.
Deletion of a putative clathrin
binding domain in the C terminal half by site specific mutagenesis abolished TOR's ability to internalize the adenosine transporter.
High magnification shows that the vesicles are coated by clathrin
9) The organism is internalized by clathrin
As a result, clathrin
mediated endocytosis (CME) has a central role in maintaining cellular homeostasis and function and mis-regulation of endocytic traffic is linked to many human diseases.
Overexpression of MARCH1 in HeLa cells causes CD98 to be trafficked via EEA1 positive compartments and late endosomes rather than clathrin
independent endocytosis .
Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin
and caveolin 2-dependent manner.
Some recently identified genes that also contribute to AD risk include CLU and PICALM (phosphatidylinositolbinding clathrin
assembly protein), among others.
Endocytosis of CT may follow one of three pathways: (i) lipid raft/caveolae mediated endocytic pathway, (ii) clathrin
mediated endocytic pathway, or (iii) ADP-ribosylation factor 6 (Arf6)-associated endocytic pathway.
endoplasmic reticulum, Golgi apparatus and clathrin
coated vesicles [24-26].
binding domain was found in the C terminal half.