Although there are multiple endocytosis pathways, the best studied is Clathrin-Mediated Endocytosis in which the membrane is coated with clathrin
proteins to form clathrin-coated pits (CCPs) which deform to intake cargo.
Another hypothesis is that, in the same manner as the CTLA-4 vesicular trafficking, also in the context of autophagy in lymphocytes, LRBA would compete with clathrin
adapter proteins, regulating this process.
Localization of the arrestin binding locus to the clathrin
It demonstrated that the uptake of D-luciferin was not related to caveolin, clathrin
, or micropinocytosis.
Zollo et al., "New insights to Clathrin
and adaptor protein 2 for the design and development of therapeutic strategies," International Journal of Molecular Sciences, vol.
For example, CLTC in KIRC, which is contained in CGC and ranked 11 with low mutated frequency 1.68% in DriverFinder, encodes a major subunit of clathrin
and is a fusion partner of TFE3.
These are a unique protein associated with intracellular transfer of membrane by coated vesicles "clathrin
," protein that plays role in protein synthesis, "elongation factor-1," a member of the mitochondrial carrier family, "alpha solute carrier family, member 13," protein that related with immune system, "immunoglobulin gamma one chain," a gene that encodes the glycodelin protein, "progestagen-associated endometrial protein (PAEP)," a major component of a specific type of lipoprotein called very low-density lipoproteins (VLDLs), and "apolipoprotein E." Additionally, 10 of 23 prenatal contigs showed similarities to putative different ribosomal proteins in NCBI with score of <80 (Table 3).
Jones et al., "Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin
coats on adipocyte plasma membranes," Molecular and Cellular Biology, vol.
Previous studies have shown that the clathrin
adaptor protein complex 2 (AP-2) is essential for constitutive receptor internalization and cellular recovery of thrombin signaling .
E glycoprotein is the most important molecule during the viral entry process as it appears to be responsible for receptor recognition and attachment to the cell surface, triggering the clathrin
mediated endocytosis and the subsequent fusion of viral and cellular membranes.
A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin