In relation to possible
clastogenic / aneugenic effects, the phytotherapeutic extracts showed no activity and also did not interfere in human lymphocyte cytokinesis.
In our study, we observed that the two highest concentrations of CPF could induce a
clastogenic process in human leukocytes, demonstrating their mutagenic potential for this type of human cells.
Traditionally, and possibly still regarded as the gold standard, the diagnosis of FA is confirmed by evaluation of the response of metaphase and interphase cells exposed to diepoxybutane or mitomycin C, two commonly used
clastogenic DNA cross-linking agents.
To score for
clastogenic damage, the %FPCV of the [G.sub.0]/[G.sub.1] peaks were analyzed, with no detectable variations (Table 2).
Sonawane, "Zincoxide nanoparticles exhibit genotoxic,
clastogenic, cytotoxic and actin depolymerization effects by inducing oxidative stress responses in macrophages and adult mice," Toxicological Sciences, vol.
The results of this study have implicated DHAP as a root growth inhibitor, mitotic-depressor and
clastogenic drug.
Lack of micronucleus inside cytoplasm revealed that ligands and their Ag(I) complexes are not
clastogenic agents, which may consider a very good feature.
Trivalent antimony is considered a
clastogenic agent; however, it is not mutagenic.
Stich, "
Clastogenic activity of caffeic acid and its relationship to hydrogen peroxide generated during autooxidation," Mutation Research, vol.
Most ADCs under clinical investigation contain cytotoxic agents that act by directly inducing DNA damage or exerting
clastogenic effects.
Preliminary results on ascorbic acid and lysine suppression of
clastogenic effect of deep-frozen sperm of the russian sturgeon (Acipenser gueldenstaedti).
Markers of genotoxicity, such as elevated levels of oxidized DNA nucleobases, bulky DNA adducts, and
clastogenic end points in leukocytes have been documented in biomonitoring studies of humans.
