Most ADCs under clinical investigation contain cytotoxic agents that act by directly inducing DNA damage or exerting
clastogenic effects.
Preliminary results on ascorbic acid and lysine suppression of
clastogenic effect of deep-frozen sperm of the russian sturgeon (Acipenser gueldenstaedti).
Markers of genotoxicity, such as elevated levels of oxidized DNA nucleobases, bulky DNA adducts, and
clastogenic end points in leukocytes have been documented in biomonitoring studies of humans.
In general, chromosome bridges and fragments indicated a
clastogenic mechanism of action of the tested substance, with some activity related to genotoxicity (action on DNA structure).
lycocarpum extracts on the cell cycle, demonstrating whether they have aneugenic or
clastogenic effects.
Agarwal K, Sharma A, Talukder G:
Clastogenic effects of copper
2011), were
clastogenic, mutagenic, and cytotoxic to normal human peripheral blood cells; boric acid, citric acid, potassium citrate and sodium citrate (Brasil, 1999) which, in agreement with Ttikoglu (2007), were cytotoxic to root meristems cells of A cepa.
A decrease in the mitotic index was observed at the highest concentration used, showing a significant
clastogenic effect (BUYUKLEYLA & RENCUZOGULLARI, 2009).
A micronucleus technique for detecting
clastogenic effects of mutagens/carcinogens in hepatocytes of rat liver in vivo.
These results indicate that ZnO nanorods at the current treatment conditions didn't cause
clastogenic effect in mature erythrocytes (% MnNCEs).
Some authors also report medicinal properties associated with the consumption of rapadura, such as decreased pulmonary lesions associated with smoking, reduced
clastogenic effects caused by arsenic, high antioxidant action and an anti-sclerotic function (Jaffe, 2012).
Clastogenic and aneugenic effects of three benzimidazole derivatives in the in vitro micronucleus test using human lymphocytes.
