classical pathway


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Related to classical pathway: alternative pathway, Complement system

classical pathway

n. Immunology
The primary pathway in the innate immune system, consisting of the activation of complement by an antigen-antibody complex.
References in periodicals archive ?
Pepper et al., "Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma," Molecular Neurodegeneration, vol.
Because conventional adenomas can harbor aberrant hypermethylation of CIMP panel markers, (49) CIMP-L CRCs can arise from either the serrated neoplasia pathway or the classical pathway. At present, methylation assays of CIMP panel markers cannot differentiate between CIMP-L serrated pathway adenocarcinomas and CIMP-L CRCs arising from the classical pathway.
Significant difference between different genotypes GG (69.49 [+ or -] 3.17 U/mL) and CG (63.59 [+ or -] 3.65 U/mL) in hemolytic activity in the classical pathway (p = 0.049) was recorded.
The complement system is a set of enzymes and bioregulators with multiple biological activities, playing a key role in both innate (alternative and lectin pathway) and acquired (classical pathway) immunity.
It was acknowledged that immune complexes formed by self-antigens and autoantibodies might activate the classical pathway, generating inflammatory mediators and resulting in tissue damage.
coli produces heme by itself via the classical pathway. Therefore, the potential AhbD from M.
Loos, "Classical pathway of activation," in The Complement System, K.T.G.
Classical pathway complement levels divide UV into normocomplementemic (NUV) and hypocomplementem-ic (HUV) forms.
For example, compared with classical pathway optimization, which focuses on enhancing the biosynthetic pathway of the nutraceutical ingredient, metabolic engineering provides a holistic view of the micro-organism, thereby optimizing the whole production organism.
Complement system can be activated by three different pathways, viz., classical pathway (CP), alternative pathway (AP), and lectin pathway (LP).
This effect was not achieved by mimicking the classical pathway of insulin action, but by activating the enzyme AMP-activated protein kinase (AMPK).