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Low CH50 was suggestive of classic complement pathway deficiency, but any specific cause for it could not be elucidated.
The cell membrane is damaged and debris activates the classic complement pathway in the infarcted myocardium.
In patients with immune complex type MPGN, the paraprotein likely forms part of the immune complex causing activation of the classic complement pathway and resulting in renal injury with both abnormal immunoglobulin and complement on immunohistochemistry.
Markham et al suggest transient glomerular deposition and clearance of small amounts of immune complexes formed during natural antibody response mechanisms in vivo, which initiates the classic complement pathway resulting in generation and deposition of C4d.