class switching


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Related to class switching: Affinity maturation, Somatic hypermutation

class switching

Physiology A step in the normal maturation of Hb during fetal development that requires switching from embryonal zeta chain, which is structurally similar to the α chain, and occurs on chromosome 16 to mature α chain production; β chain production is a 2-stage maturation process with early loss of the ε chain and the presence during fetal and early post-natal life of a γ chain, which ↓ as β chain expression is ↑. See Introduction to this volume: note.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

class switching

The change, by a B cell, of the class of an antibody it produces (for example from IgM to IgG) without a change in its specificity.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Patient with proliferative LN class switching to non-proliferative class was rare and was noted only in one patient (class III LN changed to class II LN).
Also, one should note that the IgG subclass analysis seems to give more complete information regarding the complement fixing antibodies and IgG class switching. All of the patients had standard DSA, whereas seven patients had no C1q DSA, and this observation carries over into the total numbers of DSA for both HLA Class I and II.
Murine PTEN-deficient B cells were resistant to apoptotic and migratory stimuli and demonstrated defective immunoglobulin class switching, emphasizing a role for PTEN in the regulation of B cells [21].